A new study at the University of Missouri’s Thompson Center for Autism and Neurodevelopment found that propranolol, a medication that treats high blood pressure, can also help lower anxiety for autistic kids and young adults).
Given that some autistics tend to struggle with anxiety at a far greater rate than their neurotypical peers, the new finding can significantly help such individuals in the autistic community. David Beversdorf, a clinician at the Thompson Center, led the study, which involved 69 patients over a three-year span. Compared to a placebo group, the participants who received propranolol showed significantly reduced anxiety levels at their 12-week check-up appointments while receiving the medication. The study also examined if there were significant changes in the individuals’ social communication skills, but no significant changes were found.
“The findings show that propranolol could serve as a helpful intervention for reducing anxiety for individuals with autism,” said Beversdorf, who also has appointments in the MU School of Medicine and the MU College of Arts and Science. “This drug has been around since the 1960s and is very inexpensive. Up until now, we haven’t had any known drugs that target psychiatric issues specifically for individuals with autism, so these results are very promising and can support future research.”
As a clinician, Beversdorf has seen firsthand the positive benefits propranolol can have in improving the overall quality of life for some autistic folks and their families.
“As researchers, we try our best to improve the lives of our patients, and it feels rewarding to help out,” said Beversdorf, who is a professor of radiology, neurology and psychological sciences as well as the William and Nancy Thompson Endowed Chair in Radiology. “I went into the field of neurology knowing I wanted to try to find new treatment options and interventions to benefit autitic folks.”
A long-term study by UC Davis Health researchers sheds new light on the relationship between autism traits and mental health in middle childhood. The paper, published in the journal Autism, finds that changes in core autism characteristics are related to whether children develop additional mental health challenges during their elementary school years.
“Our findings suggest that different aspects of a child’s development may affect each other over time,” explained Einat Waizbard-Bartov, a doctoral researcher in developmental psychology at the UC Davis MIND Institute and the lead author on the paper. “Core autism traits and mental health challenges likely interact throughout development.”
A key finding was that a reduction in restrictive and repetitive behaviors during elementary school was linked to the emergence of mental health challenges, lending support to the idea that these behaviors may benefit autistic individuals. An increase in social-communication difficulties during this time was also linked to anxiety and other mental health challenges.
The current study included 75 autistic children ages 6 to 11, including 15 girls. All were part of the MIND Institute’s Autism Phenome Project, a large, long-term study aimed at identifying different subtypes of autism.
Through parental interviews and questionnaires, the research team evaluated the children for mental health symptoms and restricted and repetitive behaviors, which can include seeking sensory stimulation, hand-flapping or sticking to set routines.
They tracked changes in autism characteristics using the Autism Diagnostic Observation Schedule Calibrated Severity Score.
About a fifth (21%) of the youth had more severe social-communication difficulties, as well as an increase in anxiety, ADHD and behavioral challenges. In contrast, nearly 23% had decreased restricted and repetitive behaviors but higher anxiety levels by age 11. Nearly all — 94% —met the criteria for an anxiety disorder.
About a third of the participants had both decreasing restricted and repetitive behaviors and increased social-communication difficulties.
“We were pleased to see that our results confirmed what has been suspected by other autism researchers and clinicians as well as autistic individuals, that some forms of restricted and repetitive behaviors can potentially help to self-soothe,” said David Amaral, distinguished professor in the Department of Psychiatry and Behavioral Sciences, MIND Institute faculty member and senior author on the paper.
Waizbard-Bartov notes that the findings question the wisdom of therapies that try to eliminate these behaviors.
“In light of this, when thinking about interventions, it might be that trying to eliminate repetitive behaviors without providing alternative self-soothing tools is not the ideal way to go,” she said.
The study is the first, to the authors’ knowledge, to demonstrate an association between mental health challenges and increases in the severity of social-communication difficulties for autistic children.
“This occurred in children who showed decreases in core autism traits during early childhood and whose cognitive functioning was in the typical range. We don’t currently understand why this happened. One possibility is that due to their relatively high cognitive ability, they became aware of their social challenges, and this may have contributed to increasing anxiety,” Amaral explained. “It’s definitely an area where we need more research.”
CLEVELAND – A new study from University Hospitals (UH) Connor Whole Health found patients with moderate-to-severe pain, stress, or anxiety treated at UH community hospitals reported clinically significant reductions in pain, stress, and anxiety in response to a single session of music therapy. Furthermore, the clinically significant effect on pain was not influenced by patients’ demographic or clinical characteristics, suggesting that music therapy can be effective for acute pain management across various inpatient adult populations. The findings from this study were recently published in the journal, Pain Reports, a leading journal focusing on advancing pain research.
In this retrospective study conducted between January 2017 and July 2020, researchers from UH Connor Whole Health examined the first music therapy interventions provided to 1,056 adults receiving inpatient medical care who reported pre-session pain, anxiety, and/or stress scores greater than or equal to 4 on the 0 to 10 numeric rating scale. Unlike prior studies of music therapy, which have primarily been conducted at academic medical centers, this is the first and largest investigation of the real-world effectiveness of music therapy within community medical centers. This study builds upon a history of seminal music therapy studies funded by the Kulas Foundation, the country’s leading foundation for funding scientific research in music therapy, that have investigated the efficacy of music therapy in palliative care, surgery, and sickle cell disease as well as the clinical effectiveness of music therapy within an academic cancer center.
“The music therapists at UH Connor Whole Health offer non-pharmacological frontline treatment throughout our medical system while addressing issues of stress, pain, and anxiety. Greater Cleveland residents may receive these services during hospitalizations at UH as a clinical service line offering direct evidence-based community benefit,” said Seneca Block, The Lauren Rich Fine Endowed Director of Expressive Therapies at UH Connor Whole Health. UH Connor Whole Health manages the largest health system-based music therapy program in the US with 11 board-certified music therapists who collaborate with providers across the system to help patients and their families manage the physical and emotional toll of an illness or hospitalization. Additionally, UH Connor Whole Health provides a diverse offering of integrative health and medicine modalities, including acupuncture, chiropractic, and integrative medicine consults, that are centered on patients’ entire well-being.
In “Effectiveness of Music Therapy within Community Hospitals: An EMMPIRE Retrospective Study,” researchers examined the real-world effectiveness of music therapy at eight UH community medical centers and explored variables associated with pain reduction of greater than or equal to 2 units on a 0 to 10 unit numeric rating scale.
Music therapists provided interventions including live music listening, music-assisted relaxation and imagery, and active music making to address patients’ needs including pain management, coping, stress reduction, and anxiety reduction. As part of clinical care, the music therapists assessed patients’ self-reported pain, stress, and anxiety on a 0 to 10 scale at the beginning and end of each session and documented their sessions in the electronic health record.
“What makes this research novel is our ability to streamline data collection from music therapy clinical practice to the electronic health record. We can then use these data to understand the real-world impact of music therapy throughout multiple medical centers and how best to tailor music therapy interventions to meet patients’ needs,” said Sam Rodgers-Melnick, a music therapist, first author of the study, and a co-investigator on the EMMPIRE project (Effectiveness of Medical Music Therapy Practice: Integrative Research using the Electronic Health Record). The present EMMPIRE study was funded by a 3-year grant from the Kulas Foundation to UH Hospitals.org/ConnorWholeHealth with Jeffery A. Dusek PhD, Director of Research, UH Connor Whole Health, Block and Rodgers-Melnick as prime investigators. Said Dusek, “Routine collection of patient-reported outcomes from clinical practice (also called practice-based research) is becoming increasingly common as a patient-centered quality of care measure.”
Prior research has demonstrated that reductions of at least 1.3 units on the numeric rating scale for pain are clinically significant for patients with non-cancer pain, meaning that the symptom reduction represents a meaningful difference for patients with moderate-to-severe symptoms. Reductions of at least 2 units in stress and anxiety are also considered clinically significant. In this study, patients reported clinically significant mean reductions in pain (2.04 units), anxiety (2.80 units), and stress (3.48 units) in response to music therapy, with all changes exceeding clinically significant thresholds. Additionally, of the patients reporting a pain score greater than or equal to 4, 14% fell asleep during music therapy sessions, an important observation given the sleep challenges patients with moderate-to-severe pain face during hospitalization.
Additionally, after adjusting for demographic, clinical, and operational characteristics, patients receiving a music therapy session in which pain management was a goal were 4.32 times more likely to report pain reduction greater than or equal to 2 units than patients receiving a music therapy session in which pain management was not a session goal. Said Rodgers-Melnick, “this finding raises important questions regarding how music therapists tailor their interventions to address pain when that is the goal of the session, and we will be examining these specific features of music therapy interventions in future research.
University of South Australia researchers are calling for exercise to be a mainstay approach for managing depression as a new study shows that physical activity is 1.5 times more effective than counselling or the leading medications.
Published in the British Journal of Sports Medicine, the review is the most comprehensive to date, encompassing 97 reviews, 1039 trials and 128,119 participants. It shows that physical activity is extremely beneficial for improving symptoms of depression, anxiety, and distress.
Specifically, the review showed that exercise interventions that were 12 weeks or shorter were most the effective at reducing mental health symptoms, highlighting the speed at which physical activity can make a change.
The largest benefits were seen among people with depression, pregnant and postpartum women, healthy individuals, and people diagnosed with HIV or kidney disease.
Lead UniSA researcher, Dr Ben Singh, says physical activity must be prioritised to better manage the growing cases of mental health conditions.
“Physical activity is known to help improve mental health. Yet despite the evidence, it has not been widely adopted as a first-choice treatment,” Dr Singh says.
“Our review shows that physical activity interventions can significantly reduce symptoms of depression and anxiety in all clinical populations, with some groups showing even greater signs of improvement.
“Higher intensity exercise had greater improvements for depression and anxiety, while longer durations had smaller effects when compared to short and mid-duration bursts.
“We also found that all types of physical activity and exercise were beneficial, including aerobic exercise such as walking, resistance training, Pilates, and yoga.
“Importantly, the research shows that it doesn’t take much for exercise to make a positive change to your mental health.”
Senior researcher, UniSA’s Prof Carol Maher, says the study is the first to evaluate the effects of all types of physical activity on depression, anxiety, and psychological distress in all adult populations.
“Examining these studies as a whole is an effective way to for clinicians to easily understand the body of evidence that supports physical activity in managing mental health disorders.
“We hope this review will underscore the need for physical activity, including structured exercise interventions, as a mainstay approach for managing depression and anxiety.”
Lower use of drugs for depression, anxiety, insomnia, high blood pressure, and asthma in city dwellers. Findings independent of income and educational attainment
Frequent visits to urban green spaces, such as parks and community gardens in Finland, rather than the amount, or views of them from home, may be linked to lower use of certain prescription meds, suggests research published online in Occupational & Environmental Medicine.
The observed associations between frequent green space visits and lower use of drugs for depression, anxiety, insomnia, high blood pressure, and asthma were not dependent on socio-economic position.
Exposure to natural environments is thought to be good for health, but the evidence is inconsistent, say the researchers.
They wanted to determine if the amount of residential green and blue space (bodies of water), frequency of green space visits, and views of green and blue spaces from home might be separately associated with certain prescription meds.
They chose prescription meds as a proxy for ill health and those for anxiety and insomnia, depression, high blood pressure, and asthma, mainly because they are used to treat common and potentially severe health issues.
They drew on the responses of 16,000 randomly selected residents of Helsinki, Espoo, and Vantaa, to the Helsinki Capital Region Environmental Health Survey in 2015-16. These three cities make up the largest urban area in Finland.
The survey gathered information on how city dwellers, aged at least 25, experience residential green and blue spaces within a 1 km radius of their homes.
Respondents were also asked to report their use of prescribed meds—drugs for anxiety, insomnia, and depression, collectively known as psychotropic drugs; high blood pressure and asthma drugs—if applicable, for periods ranging from within the past week up to more than a year ago or never.
They were also asked how often they spent time, or exercised outdoors, in green spaces, during May and September, with options ranging from never to 5 or more times a week.
And they were asked whether they could see green or blue spaces from any of their windows at home, and, if so, how often they took in these views, with options ranging from seldom to often.
Green areas were forests, gardens, parks, castle parks, cemeteries, zoos, herbaceous vegetation associations such as natural grassland and moors, and wetlands. Blue areas were defined as seas, lakes, and rivers.
Potentially influential factors were also considered, including health behaviours, outdoor air pollution and noise, household income and educational attainment.
The final analysis included approximately 6000 participants who provided complete information.
This showed that the amount of residential green and blue spaces, or views of them from home, weren’t associated with prescription meds for mental health, insomnia, high blood pressure or asthma.
But the frequency of green space visits was. Compared with less than one weekly visit, visiting 3-4 times weekly was associated with 33% lower odds of using mental health meds, 36% lower odds of using blood pressure meds, and 26% lower odds of using asthma meds.
The equivalent figures for visiting at least five times a week were 22%, 41%, and 24% lower.
These observed associations were weakened when weight (BMI) was factored in, particularly for asthma meds, as obesity is a known risk factor for asthma, point out the researchers.
The effects of visiting green spaces were also stronger among those reporting the lowest annual household income ( below €30, 000). But overall, the associations found didn’t depend on household income and educational attainment.
This is an observational study, so we can’t establish cause and effect. No information was available on illness severity, and better health may enable a person to spend more time outdoors.
Finland has high forest cover, while Finnish cities are relatively green, making it easy for those willing to use green spaces to access them with minimal effort, they add.
But they conclude: “Mounting scientific evidence supporting the health benefits of nature exposure is likely to increase the supply of high-quality green spaces in urban environments and promote their active use. This might be one way to improve health and welfare in cities.”
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