Tolebrutinib Research Data (New Multiple Sclerosis Drug)

This video reviews phase III clinical trial results on tolebrutinib presented at ECTRIMS. The GEMINI trials studied tolebrutinib vs. aubagio in relapsing MS, and the HERCULES trial studied tolebrutinib vs. placebo in progressive MS.

Is There A Cure For Autoimmune Disease?


What causes autoimmune disease? Dr. Osborne breaks down and answers this question during his live presentation at Torrence Memorial Medical Center. In this video, Dr. Osborne discusses the mechanisms of how the process of autoimmune disease starts. He also discusses many of the known triggers in autoimmunity, including 1. Molecular Mimicry 2. Leaky Gut (Intestinal Hyperpermeability) 3. The hygiene hypothesis 4. Gluten sensitivity 5. Infections 6. Food allergies 7. Gut imbalances 8. Nutritional deficiencies… and much more.

Specially designed video games may benefit mental health of children and teenagers

Johns Hopkins Children’s Center researchers reviewed studies of video games designed as mental health interventions for anxiety, depression and ADHD
Johns Hopkins Children’s Center researchers reviewed studies of video games designed as mental health interventions for anxiety, depression and ADHD.

In a review of previous studies, a Johns Hopkins Children’s Center team concludes that some video games created as mental health interventions can be helpful – if modest – tools in improving the mental well-being of children and teens with anxiety, depression and attention-deficit/hyperactivity disorder (ADHD).

An estimated 20% of children and teenagers between the ages of three and 17 in the U.S. have a mental, emotional, developmental or behavioural disorder. Suicidal behaviours among high school students also increased by more than 40% in the ten years before 2019, according to a report by the Agency for Healthcare Research and Quality. Other studies provide evidence that the COVID-19 pandemic’s disruptions worsened these trends, and while research suggests parents and other care givers are seeking out mental health care for children, wait times for appointments have increased.

“We found literature that suggests that even doubling the number of pediatric mental health providers still wouldn’t meet the need,” says Barry Bryant, M.D., a resident in the Department of Psychiatry and Behavioral Sciences at the Johns Hopkins University School of Medicine and first author of the new study.

In a bid to determine if so-called “gamified digital mental health interventions,” or video games designed to treat mental health conditions, benefited those with anxiety, depression and ADHD, the research team analyzed their use in randomized clinical trials for children and adolescents.

Bryant and child and adolescent psychologist Joseph McGuire, Ph.D., identified 27 such trials from the U.S. and worldwide. The studies included 2,911 participants, about half of whom were boys and half of whom were girls, between the ages of six and 17.

The digital mental health interventions varied in content, but were all created with the intent of treating ADHD, depression and anxiety. For example, for ADHD, some games involve racing or splitting attention, which requires the user to pay attention to more than one activity to succeed in gameplay. For depression and anxiety, some of the interventions taught psychotherapy-oriented concepts in a game format. All games were conducted on technology platforms like computers, tablets, video game consoles and smartphones. The video games are available to users in various ways — some are available online, while others required access through specific research teams involved in the studies.

Outcome measurements varied depending on the study. However, the Johns Hopkins research team was able to standardize effect sizes using a random-effects model so that a positive result was indicated when interventions performed better than control conditions. Hedges g, a statistic used to measure effect size, was used to quantify treatment effects overall in the studies reviewed.

Researchers also examined factors that led to improved benefit from digital mental health interventions. Specific factors related to video game delivery (i.e., interventions on computers and those with preset time limits) and participants (i.e., studies that involved more boys) were found to positively influence therapeutic effects. Researchers say these findings suggest ways to improve the current modest symptom benefit.

“While the benefits are still modest, our research shows that we have some novel tools to help improve children’s mental health — particularly for ADHD and depression — that can be relatively accessible to families,” says Joseph McGuire, PhD, an author of the study and an associate professor of psychiatry and behavioural sciences in the school of medicine. “So if you are a paediatrician and you’re having trouble getting your pediatric patient into individual mental health care, there could be some gamified mental health interventions that could be nice first steps for children while waiting to start individual therapy.”

Obesity in mums doubles the possibility of autism in babies? Does this research chime with your experience?

When screening pregnant women for gestational diabetes, casual blood glucose testing misses 70% of the cases. This Kobe University study should encourage obstetricians to depend on more reliable tests to help prevent pregnancy complications and the development of type II diabetes in mothers and children.
Children born to mothers with obesity before and during pregnancy have a higher possibility of neuropsychiatric and behavioural conditions, such as autism and attention deficit hyperactivity disorder (ADHD), according to new research from the University of South Australia. 


Funded by the Centre of Research Excellence in Health in Preconception & Pregnancy and conducted in partnership with Curtin University, Monash University, SAHMRI, and a team of national institutions, the systematic review and meta-analysis of more than 3.6 million mother-child pairs across 42 epidemiological studies found that obesity during pregnancy: 

Increases the chance of ADHD in children by 32%.
Doubles the chance of developing autism in children (by 2.23 times).
Increases the possibility of conduct disorders by 16%

 
The study also found that maternal pre-conception obesity or overweight was linked with an increased risk of ADHD, autism, conduct disorder and psychotic disorder, as well as a 30% increased risk in both externalising symptoms and peer relationship problems.
 
 
“Maternal obesity has long been associated with a range of adverse perinatal outcomes, including preterm birth, low birth weight, stillbirth, and it is also linked with macrosomia or high birthweight,” Dr Duko says.
 
“In this study, we examined maternal overweight and obesity before and during pregnancy, finding that both are significantly linked with psychiatric and behavioural problems in children later in life, specifically autism, ADHD and peer relationship problems.
 
“Given the rising global obesity rates among women of reproductive age, and the growing numbers of children identified with neurodiverse conditions, it’s important that we acknowledge the potential long-term consequences of maternal adiposity on child mental health.”
 
In Australia, approximately 1 in 150 people are autistic , and more than 8% of children aged 4-11 are diagnosed with ADHD. Globally, 1 in 8 people live with obesity.

8 Incredible Foods That Calm Autoimmune Diseases

Discover how specific foods can help alleviate the symptoms of autoimmune diseases and improve your overall health.

8. Sunflower Seeds Sunflower seeds are a great way to boost your immune system and alleviate the symptoms of autoimmune diseases. They are packed with nutrients, especially vitamin E, that can help rebalance your immune cells and fight chronic inflammation.

7. Extra Virgin Olive OilRecent studies have shown that extra virgin olive oil contains components like oleic acid and oleocanthal antioxidants, which play an essential role in managing inflammation.

6. Sweet Potatoes Sweet potatoes are a versatile and nutrient-packed option that can benefit your immune system. They do not contain nightshade alkaloids and are rich in potassium, beta-carotene antioxidants, vitamin C, and vitamin A.

5. Fatty Fish Certain types of fatty fish, such as salmon, sardines, herring, mackerel, or anchovies, which are rich in omega-3 fatty acids EPA and DHA, can inhibit an inflammatory marker called C-reactive protein, which has been linked to worsening autoimmune reactions.

4. Turmeric Turmeric contains the active ingredient curcumin, which has been found to reduce the production, activation, and migration of antibodies, making it an excellent tool for autoimmune balance.

3. Green Tea Green tea is packed with epigallocatechin-3-gallate (EGCG), a potent antioxidant that has been found to reduce the production of cytokine cells, which play a role in autoimmune diseases.

2. Mushrooms Mushrooms are one of the few plant sources of Vitamin D and are especially rich in this nutrient, which is beneficial for the immune system.

1. Leafy Greens are packed with a range of nutrients and antioxidants that help fight inflammation and protect the body against free radical damage.