This video reviews phase III clinical trial results on tolebrutinib presented at ECTRIMS. The GEMINI trials studied tolebrutinib vs. aubagio in relapsing MS, and the HERCULES trial studied tolebrutinib vs. placebo in progressive MS.
Is There A Cure For Autoimmune Disease?
What causes autoimmune disease? Dr. Osborne breaks down and answers this question during his live presentation at Torrence Memorial Medical Center. In this video, Dr. Osborne discusses the mechanisms of how the process of autoimmune disease starts. He also discusses many of the known triggers in autoimmunity, including 1. Molecular Mimicry 2. Leaky Gut (Intestinal Hyperpermeability) 3. The hygiene hypothesis 4. Gluten sensitivity 5. Infections 6. Food allergies 7. Gut imbalances 8. Nutritional deficiencies… and much more.
Specially designed video games may benefit mental health of children and teenagers
In a review of previous studies, a Johns Hopkins Children’s Center team concludes that some video games created as mental health interventions can be helpful – if modest – tools in improving the mental well-being of children and teens with anxiety, depression and attention-deficit/hyperactivity disorder (ADHD).
An estimated 20% of children and teenagers between the ages of three and 17 in the U.S. have a mental, emotional, developmental or behavioural disorder. Suicidal behaviours among high school students also increased by more than 40% in the ten years before 2019, according to a report by the Agency for Healthcare Research and Quality. Other studies provide evidence that the COVID-19 pandemic’s disruptions worsened these trends, and while research suggests parents and other care givers are seeking out mental health care for children, wait times for appointments have increased.
“We found literature that suggests that even doubling the number of pediatric mental health providers still wouldn’t meet the need,” says Barry Bryant, M.D., a resident in the Department of Psychiatry and Behavioral Sciences at the Johns Hopkins University School of Medicine and first author of the new study.
In a bid to determine if so-called “gamified digital mental health interventions,” or video games designed to treat mental health conditions, benefited those with anxiety, depression and ADHD, the research team analyzed their use in randomized clinical trials for children and adolescents.
Bryant and child and adolescent psychologist Joseph McGuire, Ph.D., identified 27 such trials from the U.S. and worldwide. The studies included 2,911 participants, about half of whom were boys and half of whom were girls, between the ages of six and 17.
The digital mental health interventions varied in content, but were all created with the intent of treating ADHD, depression and anxiety. For example, for ADHD, some games involve racing or splitting attention, which requires the user to pay attention to more than one activity to succeed in gameplay. For depression and anxiety, some of the interventions taught psychotherapy-oriented concepts in a game format. All games were conducted on technology platforms like computers, tablets, video game consoles and smartphones. The video games are available to users in various ways — some are available online, while others required access through specific research teams involved in the studies.
Outcome measurements varied depending on the study. However, the Johns Hopkins research team was able to standardize effect sizes using a random-effects model so that a positive result was indicated when interventions performed better than control conditions. Hedges g, a statistic used to measure effect size, was used to quantify treatment effects overall in the studies reviewed.
Researchers also examined factors that led to improved benefit from digital mental health interventions. Specific factors related to video game delivery (i.e., interventions on computers and those with preset time limits) and participants (i.e., studies that involved more boys) were found to positively influence therapeutic effects. Researchers say these findings suggest ways to improve the current modest symptom benefit.
“While the benefits are still modest, our research shows that we have some novel tools to help improve children’s mental health — particularly for ADHD and depression — that can be relatively accessible to families,” says Joseph McGuire, PhD, an author of the study and an associate professor of psychiatry and behavioural sciences in the school of medicine. “So if you are a paediatrician and you’re having trouble getting your pediatric patient into individual mental health care, there could be some gamified mental health interventions that could be nice first steps for children while waiting to start individual therapy.”
Obesity in mums doubles the possibility of autism in babies? Does this research chime with your experience?
8 Incredible Foods That Calm Autoimmune Diseases
Discover how specific foods can help alleviate the symptoms of autoimmune diseases and improve your overall health.
8. Sunflower Seeds Sunflower seeds are a great way to boost your immune system and alleviate the symptoms of autoimmune diseases. They are packed with nutrients, especially vitamin E, that can help rebalance your immune cells and fight chronic inflammation.
7. Extra Virgin Olive OilRecent studies have shown that extra virgin olive oil contains components like oleic acid and oleocanthal antioxidants, which play an essential role in managing inflammation.
6. Sweet Potatoes Sweet potatoes are a versatile and nutrient-packed option that can benefit your immune system. They do not contain nightshade alkaloids and are rich in potassium, beta-carotene antioxidants, vitamin C, and vitamin A.
5. Fatty Fish Certain types of fatty fish, such as salmon, sardines, herring, mackerel, or anchovies, which are rich in omega-3 fatty acids EPA and DHA, can inhibit an inflammatory marker called C-reactive protein, which has been linked to worsening autoimmune reactions.
4. Turmeric Turmeric contains the active ingredient curcumin, which has been found to reduce the production, activation, and migration of antibodies, making it an excellent tool for autoimmune balance.
3. Green Tea Green tea is packed with epigallocatechin-3-gallate (EGCG), a potent antioxidant that has been found to reduce the production of cytokine cells, which play a role in autoimmune diseases.
2. Mushrooms Mushrooms are one of the few plant sources of Vitamin D and are especially rich in this nutrient, which is beneficial for the immune system.
1. Leafy Greens are packed with a range of nutrients and antioxidants that help fight inflammation and protect the body against free radical damage.