In this video, I share 6 reasons you might need to switch your MS Medication? Listen to the end of the video and I share one big reason NOT to stop treatment.
Multiple Sclerosis
Multiple sclerosis – robotic system feeds people with severe mobility limitations
Cornell researchers have developed a robotic feeding system that uses computer vision, machine learning and multimodal sensing to safely feed people with severe mobility limitations, including those with spinal cord injuries, cerebral palsy and multiple sclerosis.
Tapomayukh “Tapo” Bhattacharjee, assistant professor of computer science in the Cornell Ann S. Bowers College of Computing and Information Science and senior developer behind the system, went on to say, “The challenge intensifies when feeding individuals with additional complex medical conditions.”
A paper on the system, “Feel the Bite: Robot-Assisted Inside-Mouth Bite Transfer using Robust Mouth Perception and Physical Interaction-Aware Control,” was presented at the Human-Robot Interaction conference, It received a Best Paper Honorable Mention recognition, while a demo of the research team’s broader robotic feeding system received a Best Demo Award.
A leader in assistive robotics, Bhattacharjee and his EmPRISE Lab have spent years teaching machines the complex process by which humans feed themselves. It’s a complicated challenge to teach a machine everything from identifying food items on a plate to picking them up and then transferring them inside the mouth of a care recipient.
“This last 5 centimetres, from the utensil to inside the mouth, is extremely challenging,” Bhattacharjee said.
Some care recipients may have very limited mouth openings, measuring less than 2 centimetres, while others experience involuntary muscle spasms that can occur unexpectedly, even when the utensil is inside their mouth, Bhattacharjee said. Further, he said that some can only bite food at specific locations inside their mouth, which they indicate by pushing the utensil using their tongue.
“Current technology only looks at a person’s face once and assumes they will remain still, which is often not the case and can be very limiting for care recipients,” said Rajat Kumar Jenamani, the paper’s lead author and a doctoral student in the field of computer science.
To address these challenges, researchers developed and outfitted their robot with two essential features: real-time mouth tracking that adjusts to users’ movements, and a dynamic response mechanism that enables the robot to detect the nature of physical interactions as they occur, and react appropriately. This enables the system to distinguish between sudden spasms, intentional bites and user attempts to manipulate the utensil inside their mouth, researchers said.
The robotic system successfully fed 13 individuals with diverse medical conditions in a user study spanning three locations: the EmPRISE Lab on the Cornell Ithaca campus, a medical center in New York City, and a care recipient’s home in Connecticut. Users of the robot found it to be safe and comfortable, researchers said.
“This is one of the most extensive real-world evaluations of any autonomous robot-assisted feeding system with end-users,” Bhattacharjee said.
The team’s robot is a multi-jointed arm that holds a custom-built utensil at the end that can sense the forces being applied on it. The mouth tracking method – trained on thousands of images featuring various participants’ head poses and facial expressions – combines data from two cameras positioned above and below the utensil. This allows for precise detection of the mouth and overcomes any visual obstructions caused by the utensil itself, researchers said. This physical interaction-aware response mechanism uses both visual and force sensing to perceive how users are interacting with the robot, Jenamani said.
“We’re empowering individuals to control a 20-pound robot with just their tongue,” he said.
He cited the user studies as the most gratifying aspect of the project, noting the significant emotional impact of the robot on the care recipients and their caregivers. During one session, the parents of a daughter with schizencephaly quadriplegia, a rare birth defect, witnessed her successfully feed herself using the system.
“It was a moment of real emotion; her father raised his cap in celebration, and her mother was almost in tears,” Jenamani said.
While further work is needed to explore the system’s long-term usability, its promising results highlight the potential to improve care recipients’ level of independence and quality of life, researchers said.
“It’s amazing,” Bhattacharjee said, “and very, very fulfilling.”
Interferon-beta regulates excessive alternative splicing in multiple sclerosis
The authoritative peer-reviewed source for research, analysis, and advances on the therapeutic role of cytokines and IFNs. CREDIT Mary Ann Liebert, Inc.
A new study found extensive alternative splicing of messenger RNA in the blood cells of untreated multiple sclerosis patients compared to healthy controls. The study, which showed that highly dysregulated alternative splicing was largely corrected by interferon-ß (IFN- ß) therapy, was published in the peer-reviewed Journal of Interferon & Cytokine Research (JICR).
Anthony Reder and Xuan Feng, from the University of Chicago Department of Medicine, and coauthors reported that during long-term IFN- ß therapy, multiple sclerosis exacerbations were linked to more dysregulated alternative splicing. Furthermore, alternative splicing predicted future clinical exacerbations.
“Alternative splicing is a potential biomarker warning of disease activity and for predicting therapeutic response to IFN- ß treatment,” stated the investigators. “Alternative splicing in multiple sclerosis suggests new directions for investigation of disease mechanisms, therapeutic monitoring, and drug choices in multiple sclerosis and in autoimmune and viral diseases.”
“These novel findings demonstrate that measurement of alternatively spliced mRNA transcript levels in blood leukocytes from patients with multiple sclerosis may help to predict clinical responsiveness to IFN-b therapy,” says Journal of Interferon & Cytokine Research Executive Editor Raymond Donnelly, PhD.
Multiple sclerosis and menopause
The roles of female hormones, oestradiol, progesterone, and testosterone, are very important in our brains and bodies. In this video, Dr Louise Newson discusses the neuroprotective effects of these hormones. You can hear her talk about female hormones and multiple sclerosis (MS), as many women find their symptoms worsen during perimenopause and menopause. Hormones are likely to be important, yet many neurologists are not trained in safe prescribing of hormones, including testosterone.
Managing Multiple Sclerosis Symptoms: Effective Ways to Reduce Inflammation
Managing MS symptoms with medication, diet, and lifestyle changes can help us live well with MS. In this video, I share information on how MS is an inflammatory disease and tips on how diet and lifestyle changes can help reduce inflammation. Reducing inflammation may help reduce symptoms and improve our quality of life. And who doesn’t want reduced symptoms and a better quality of life?!