Medical expert reveals everything you need to know about Herpes.

Abbas Kanani, Lead medical advisor at Chemist Click reveals everything you need to know about this common STI.

What is the difference between HSV-1 and HSV-2?

They key difference between the two is where you find them on your body. For example, most of HSV-1 infections are oral herpes which are transmitted through oral contact. These appear as blisters on the side of the mouth otherwise known as cold sores. HSV-2 is spread predominantly through sexual contact. The infection occurs in the genital area causing blisters and sores to appear.

What are the symptoms of genital herpes?

  • Small blisters around the genital, anus, thigh or buttock area that burst, leaving open sores that are usually red
  • Burning, itching or a tingling sensation around your genitals
  • Vaginal discharge that is unusual
  • Pain on urination

When and how should I get tested for genital herpes?

You should get tested for genital herpes as soon as you develop symptoms. You can get tested at your local sexual health clinic or order a test kit online. The test involves swabbing a blister, the practitioner will try to swab and oozing lesion for a more accurate test.

When do the symptoms of genital herpes appear?

Symptoms for those who have contracted herpes for the first time usually occur within 1-2 weeks, this is known as the incubation period where the virus is multiplying in your body before it causes an outbreak. Re-infections can occur at any time, most usually appearing when your immune system is down.

How long do the symptoms of genital herpes last for?

The first outbreak of herpes is usually the most severe, lasting around 2-3 weeks. After this, outbreaks usually last for around a week, depending on when you started anti-viral treatment. Before an outbreak, you may notice a sensation of tingling, burning or itching around the genital region. This is usually a sign of an outbreak and the best time to start treatment, ideally before blisters begin to appear.

How often do genital herpes outbreaks occur?

Outbreaks of genital herpes vary, depending on the person. Whilst some people will never, or very rarely experience outbreaks, others will experience outbreaks of genital herpes several times a year. It is important to keep yourself healthy, as a strong immune system can help to suppress the herpes simplex virus.

Is herpes simplex curable?

There is no cure for herpes, but certain anti-viral treatments such as aciclovir and valaciclovir can relieve the symptoms of genital herpes. It is a common condition that many of us live a normal healthy life with.

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Long COVID and severe COVID-19 infections associated with Epstein-Barr virus reactivation

The dynamics of EBV viral capsid antigen (VCA) IgM titers, EBV early antigen-diffuse (EA-D) IgG titers, and serum EBV DNA over time after EBV infection or reactivation. CREDIT Jeffrey E. Gold, Ramazan A. Okyay, Warren E. Licht, and David J. Hurley

Two recently published studies available on the National Institutes of Health (NIH) website indicate Epstein-Barr virus (EBV) reactivation may play a role both in the development of long COVID symptoms, as well as severe COVID-19 cases.

The first evidence linking EBV reactivation to long COVID symptoms was discovered by Gold et al. (2021) and published in Pathogens. This study can be viewed on the NIH website here: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233978/

“We ran Epstein-Barr virus serological tests on COVID-19 patients at least 90 days after testing positive for SARS-CoV-2 infection, comparing EBV reactivation rates of those with long COVID symptoms to those who never experienced long COVID symptoms,” said lead study author Jeffrey E. Gold of World Organization. “We found over 73% of COVID-19 patients who were experiencing long Covid symptoms were also positive for EBV reactivation.”

Another group of researchers, Chen et al. (2021), found EBV reactivation may also be associated with COVID-19 severity. Their report published in Scientific Reports by Nature is available here: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8149409/

According to Gold, more than 95% of health adults will test positive for latent EBV infection, identified by testing for the presence of EBV VCA IgG and/or EBV nuclear antigen 1 (EBNA-1) IgG. EBV reactivation, on the other hand, is identified by further testing for the presence of EBV EA-D IgG, EBV VCA IgM, and/or circulating EBV DNA.

David J. Hurley, PhD, a professor and molecular microbiologist at the University of Georgia and coauthor of the Pathogens study said, “We found similar rates of EBV reactivation in those who had long COVID symptoms for months, as in those with long COVID symptoms that began just weeks after testing positive for COVID-19. This indicated to us that EBV reactivation likely occurs simultaneously or soon after COVID-19 infection.”

According to Gold, other diseases and stressors can also trigger EBV reactivation, this is not exclusive to COVID-19. The inflammation response from SARS-CoV-2 infection, however, appears more successful than many other stressors at triggering EBV reactivation. While EBV reactivation may not be responsible for all cases of recurring fatigue or brain fog after recovering from COVID-19, evidence indicates that it likely plays a role in many or even most cases.

The Pathogens study found that nearly one-third of 185 people surveyed who had tested positive for COVID-19 ended up with long haul symptoms, even some who were initially asymptomatic. This percentage of long term sequelae after COVID-19 infection was similar to the percentage found in a separate study Sequelae in Adults at 6 Months After COVID-19 Infection published in JAMA Network Open.

The relationship between SARS-CoV-2 and EBV reactivation described in these studies open up new possibilities for the diagnosis and treatment of initial COVID-19 infection as well as long COVID. The researchers of the study in Pathogens indicated that it may be prudent to test patients newly positive for COVID-19 for evidence of EBV reactivation indicated by positive EBV EA-D IgG, EBV VCA IgM, or serum EBV DNA tests. If patients show signs of EBV reactivation, they can be treated early to reduce the intensity and duration of EBV replication, which may help inhibit the development of long COVID.

While there is no available vaccine to prevent EBV infection, on July 26, 2021 a phase 1, open-label study to evaluate the safety and immunogenicity of an EBV vaccine sponsored by the National Institute of Allergy and Infectious Diseases (NIAID) at NIH is expected to begin.

“As evidence mounts supporting a role for EBV reactivation in the clinical manifestation of acute COVID-19, this study further implicates EBV in the development of long COVID,” said Lawrence S. Young, PhD, a virologist at the University of Warwick speaking about the Pathogens study. “If a direct role for EBV reactivation in long COVID is supported by further studies, this would provide opportunities to improve the rational diagnosis of this condition and to consider the therapeutic value of anti-herpesvirus agents such as ganciclovir.”

Should masks be worn outdoors?

Should masks be worn outdoors?

Mask wearing by the public, particularly outdoors, remains controversial. But should masks be worn outside, in some circumstances, to help reduce covid-19 virus transmission – or should efforts focus on reducing indoor transmission where risks are greater?

Experts debate the issue in The BMJ today.

Babak Javid at the University of California San Francisco and colleagues acknowledge that the risk of covid-19 virus transmission is far greater indoors than outdoors. Nor do they support policies that mandate masking outdoors when someone is alone or only with members of one household.

But they argue that wearing masks outdoors, particularly at large outdoor gatherings with prolonged close interactions, should be normalised because it may reduce virus transmission and encourage mask wearing indoors, where risks are greater.

They say fears of increased transmission after mass protests in support of the Black Lives Matter movement were not realised, whereas the mass outdoor Sturgis Motorcycle Rally in South Dakota, USA, is thought to have been the trigger for a huge superspreading-type event.

One proposed reason for these differences is that the Sturgis Rally was associated with lower compliance with measures such as mask wearing and physical distancing that are associated with decreased transmission risk, they explain.

They also point to data from the US and Germany showing that regions with public mask mandates have had a lower impact from the virus, while countries with early adoption of face coverings for the public also achieved an earlier acceptance of a social norm during the pandemic.

In summary, they argue that “wearing masks outdoors, particularly at large outdoor gatherings such as sporting events or other settings where it will be difficult to maintain physical distance for prolonged periods, which may have a low but measurable risk of seeding a superspreading event – as well as normalising mask wearing behaviour in general – will bring benefits in reducing risks during the pandemic phase of covid-19.”

But Dr Muge Cevik at the University of St Andrews and colleagues argue that outdoor transmission contributes very little to overall infection rates and efforts should focus on reducing indoor transmission.

No confirmed sizeable covid-19 clusters or “superspreader” events have been outdoors-only, they say. While the Sturgis Rally in South Dakota or the Rose Garden outbreak at the White House are frequently cited as evidence for outdoor-only superspreading events, these events had sustained and multi-day indoor components. For instance, epidemiological investigation of Sturgis Rally found cases linked to restaurants and workplaces.

Given the low risk of transmission outdoors, recommendations or mandates for outdoor masking may seem arbitrary, affecting people’s trust and sustained energy to engage in higher yield interventions, such as indoor mask use or staying home if sick, they write.

What’s more, an outdoor mask requirement “might serve as a disincentive to be outdoors, which could worsen social isolation.”

Equity concerns are also vital, they add, because people who have access to back gardens or can afford private transport to less population dense areas can enjoy the outdoors unmasked, while many others without such privileges or resources cannot enjoy fresh air or exercise unmasked in settings where mask use is universally mandated outdoors.

They believe the public should be informed about the evolving scientific understanding of transmission mechanisms and should be encouraged to be most vigilant in indoor settings, while noting that prolonged and close contact outdoors may pose a risk.

Ultimately, outdoor mask mandates may be popular in some settings, as they are among the most “visible interventions” purporting to demonstrate decisive leadership, they write.

“However, these mandates do little to tackle the real transmission risks or to address outcomes of socioeconomic inequities and structural racism, driving a disproportionate number of the infections and consistent disparities observed worldwide,” they conclude.

A linked article asks what do we know about airborne transmission of SARS-CoV-2? The World Health Organization is currently of the opinion that viral transmission by aerosols, while possible for covid-19, is not the main route by which SARS-CoV-2 spreads.

And in a linked commentary, The BMJ‘s patient editor explains why she wears a mask indoors and out. “Wearing a mask doesn’t mean that you are weak or cowardly. It’s a way to protect vulnerable people around you,” she writes. “I am vaccinated, yet I wear a mask inside or outside in solidarity with those who are still vulnerable.”