Magali explains how one spectrum disorder is not the same as the other and how she managed to cope with her disorder and made it into a strength. Magali De Reu is a 28-year old serving the tech/startup community in Belgium, Western Europe, and recently, the US. Living with Asperger Syndrome, she is particularly passionate about examining and delving into the ways in which people communicate.
While it is true that autism is largely a male disorder, women suffer from it too. But their unique stories often go untold. Sarai Pahla is a young woman from Zimbabwe who grew up in South Africa and has been living in Germany for a couple of years. She suffers from Asperger syndrome, a high functioning form of autism. In her talk, she describes the difficulties she has had to master in the course of her life. And she delivers a manual for those who dare to engage in a relationship with autistic women.
In this video, I share the BEST diet for people who use wheelchairs! Wheelchair Weight Loss?
The device can be worn on the upper arm while the wearer goes about their day. CREDIT Laboratory for Nanobioelectronics / UC San Diego
Imagine being able to measure your blood sugar levels, know if you’ve had too much to drink, and track your muscle fatigue during a workout, all in one small device worn on your skin. Engineers at the University of California San Diego have developed a prototype of such a wearable that can continuously monitor several health stats—glucose, alcohol, and lactate levels—simultaneously in real-time.
The device is about the size of a stack of six quarters. It is applied to the skin through a Velcro-like patch of microscopic needles, or microneedles, that are each about one-fifth the width of a human hair. Wearing the device is not painful—the microneedles barely penetrate the surface of the skin to sense biomolecules in interstitial fluid, which is the fluid surrounding the cells beneath the skin. The device can be worn on the upper arm and sends data wirelessly to a custom smartphone app.
Researchers at the UC San Diego Center for Wearable Sensors describe their device in a paper published May 9 in Nature Biomedical Engineering.
“This is like a complete lab on the skin,” said center director Joseph Wang, a professor of nanoengineering at UC San Diego and co-corresponding author of the paper. “It is capable of continuously measuring multiple biomarkers at the same time, allowing users to monitor their health and wellness as they perform their daily activities.”
Most commercial health monitors, such as continuous glucose monitors for patients with diabetes, only measure one signal. The problem with that, the researchers said, is that it leaves out information that could help people with diabetes, for example, manage their disease more effectively. Monitoring alcohol levels is useful because drinking alcohol can lower glucose levels. Knowing both levels can help people with diabetes prevent their blood sugar from dropping too low after having a drink. Combining information about lactate, which can be monitored during exercise as a biomarker for muscle fatigue, is also useful because physical activity influences the body’s ability to regulate glucose.
“With our wearable, people can see the interplay between their glucose spikes or dips with their diet, exercise and drinking of alcoholic beverages. That could add to their quality of life as well,” said Farshad Tehrani, a nanoengineering Ph.D. student in Wang’s lab and one of the co-first authors of the study.
Microneedles merged with electronics
The wearable consists of a microneedle patch connected to a case of electronics. Different enzymes on the tips of the microneedles react with glucose, alcohol and lactate in interstitial fluid. These reactions generate small electric currents, which are analyzed by electronic sensors and communicated wirelessly to an app that the researchers developed. The results are displayed in real time on a smartphone.
An advantage of using microneedles is that they directly sample the interstitial fluid, and research has shown that biochemical levels measured in that fluid correlate well with levels in blood.
“We’re starting at a really good place with this technology in terms of clinical validity and relevance,” said Patrick Mercier, a professor of electrical and computer engineering at UC San Diego and co-corresponding author of the paper. “That lowers the barriers to clinical translation.”
The microneedle patch, which is disposable, can be detached from the electronic case for easy replacement. The electronic case, which is reusable, houses the battery, electronic sensors, wireless transmitter and other electronic components. The device can be recharged on any wireless charging pad used for phones and smartwatches.
Integrating all these components together into one small, wireless wearable was one of the team’s biggest challenges. It also required some clever design and engineering to combine the reusable electronics, which must stay dry, with the microneedle patch, which gets exposed to biological fluid.
“The beauty of this is that it is a fully integrated system that someone can wear without being tethered to benchtop equipment,” said Mercier, who is also the co-director of the UC San Diego Center for Wearable Sensors.
Testing
The wearable was tested on five volunteers, who wore the device on their upper arm, while exercising, eating a meal, and drinking a glass of wine. The device was used to continuously monitor the volunteers’ glucose levels simultaneously with either their alcohol or lactate levels. The glucose, alcohol and lactate measurements taken by the device closely matched the measurements taken respectively by a commercial blood glucose monitor, Breathalyzer, and blood lactate measurements performed in the lab.
Next steps
Farshad Tehrani and fellow co-first author Hazhir Teymourian, who is a former postdoctoral researcher in Wang’s lab, co-founded a startup company called AquilX to further develop the technology for commercialization. Next steps include testing and improving upon how long the microneedle patch can last before being replaced. The company is also excited about the possibility of adding more sensors to the device to monitor medication levels in patients and other health signals.
In this video, I’m joined by visual artist Emily Sunez, who lives with multiple chronic conditions. She is the author and illustrator of The Healing Journal: Guided Prompts and Inspiration for Life with Illness. We talk about the book, how she became inspired to create this during a difficult time in her life, why making time for any creative endeavour can help you manage life with illness better, and much more!