A constellation of symptoms presages first definitive signs of multiple sclerosis Study is largest-ever effort to identify symptoms that appear before MS diagnosis

Symptoms of MS

Symptoms of MS

During the five years before people develop the first clinically recognized signs of multiple sclerosis (MS), they are up to four times more likely to be treated for nervous system disorders such as pain or sleep problems. They are 50 per cent more likely to visit a psychiatrist, according to new research from the University of British Columbia.

The study, the largest-ever effort to document symptoms of people before they know they have MS, could enable physicians to diagnose the disease – and thus start treating it – earlier, therefore possibly slowing the damage it causes to the brain and spinal cord.

MS results from the body’s immune system attacking myelin, the fatty material that insulates neurons and enables rapid transmission of electrical signals. When myelin is damaged, communication between the brain and other body parts is disrupted, leading to vision problems, muscle weakness, difficulty with balance and coordination, and cognitive impairments.

Because the symptoms are varied, often associated with other disorders, and can be transitory, diagnosing MS can be a challenge. Confirmation of the disease usually is done by magnetic resonance imaging (MRI), a test of nerve impulses, or an examination of spinal fluid.

Canada has one of the highest rates of MS in the world for reasons that elude scientists.

The researchers, led by Helen Tremlett, a Professor in the Division of Neurology at UBC, examined the health records of 14,000 people with multiple sclerosis from B.C., Saskatchewan, Manitoba and Nova Scotia between 1984 and 2014 and compared them to the health records of 67,000 people without the disease.

Tremlett and former postdoctoral fellow José Wijnands found that fibromyalgia, a condition involving widespread musculoskeletal pain, was more than three times as common in people who were later diagnosed with MS, and irritable bowel syndrome was almost twice as common.

Two other conditions with markedly higher rates among people to be diagnosed with MS are migraine headaches and any mood or anxiety disorder, which includes depression, anxiety and bipolar disorder.

The higher rates of those illnesses also correspond with higher use of medications for musculoskeletal disorders, nervous system disorders, and disorders of the genito-urinary tract, along with antidepressants and antibiotics.

The study, published in Multiple Sclerosis Journal, provides definitive evidence that MS can be preceded by early symptoms – known as a prodrome – that aren’t considered “classic” manifestations of the disease, like blurred vision or numbness or weakness in the limbs. As recently as 2000, medical textbooks asserted that MS did not have a prodrome.

“The existence of such ‘warning signs’ are well-accepted for Alzheimer’s disease and Parkinson’s disease, but there has been little investigation into a similar pattern for MS,” said Tremlett, a Canada Research Chair in Neuroepidemiology and Multiple Sclerosis and member of the Djavad Mowafaghian Centre for Brain Health. “We now need to delve deeper into this phenomenon, perhaps using data-mining techniques. We want to see if there are discernible patterns related to sex, age, or the ‘type’ of MS they eventually develop.”

Early signs of MS ( Multiple Sclerosis) I Common pre-diagnosis symptoms that are easily missed

Early signs of MS ( Multiple Sclerosis) I Common pre-diagnosis symptoms  that are easily missed - YouTube


How would you know if you have MS? In this video I talk about my first symptoms I had before I was diagnosed as well as some of the other common ones I’ve learned about (or experienced!) since my diagnosis and know about from talking with fellow MSers!

SIGNS YOU MIGHT HAVE MULTIPLE SCLEROSIS

SIGNS YOU MIGHT HAVE MULTIPLE SCLEROSIS | MS SIGNS & SYMPTOMS - YouTube


This is a video about MY own signs and symptoms that I had Multiple Sclerosis or MS, if you have any or all of these symptoms it absolutely does not mean that you definitely have MS, please consult your doctor if you suspect you have MS.



Multiple Sclerosis. How long did it take your to get diagnosed with Multiple Sclerosis after you first symptoms of MS had presented themselves?




Stress Management for Multiple Sclerosis

 Multiple Sclerosis

As regular readers of this blog know we are running a series poll and blogs about our readers

diagnosis of multiple sclerosis.

You can read more here https://patienttalk.org/?p=399.  We have, at time of blogging, 74 responses so please drop over and find out more.




In today’s poll we are interested in finding out how long it took you too get diagnosed with  with multiple sclerosis after your first symptoms of MS had presented themselves.

Please take our poll below.  If you would like to add anything more please feel free to use the comments box.

Thanks very much in advance





MarilynRoberts

My car and a palm tree got into a nasty fight. Guess who won? I had a piece of titanium and 5 pins surgically installed to hold together the hip that my left leg was shoved through. Three years later an ER tech told me privately that the metal may have given me MS. If I could get that officially in writing we’d be having this conversation in my beach house in the virgin islands.