Having a sweet tooth is linked to higher risk of depression, diabetes, and stroke, study finds

People with a preference for sweets are at a higher risk of developing depression, diabetes, and suffering a stroke, according to new research from the University of Surrey.
People with a preference for sweets are at a higher risk of developing depression, diabetes, and suffering a stroke, according to new research from the University of Surrey.

The study, which was published in the Journal of Translational Medicine, utilized anonymized data on the food preferences of 180,000 volunteers from the UK Biobank. Artificial intelligence was employed to categorize them into three general profiles:

  • Health-conscious: prefer fruits and vegetables over animal-based and sweet foods. 
  • Omnivore: Likes most foods, including meats, fish, and some vegetables, as well as sweets and desserts. 
  • Sweet tooth: Prefer sweet foods and sugary drinks and is less interested in healthier options like fruit and vegetables.  

The Surrey team analyzed UK Biobank data on blood samples, measuring 2,923 proteins and 168 metabolites to observe how these levels varied in each group.

Proteins are essential for various functions in the body, such as fighting infections, muscle contractions, and cognitive processes. Metabolites, on the other hand, are small molecules produced during digestion and other chemical processes in the body, providing valuable insights into our body’s functioning. By comparing these blood-based proteins and metabolites, researchers can gain a better understanding of the biological variances between different groups.

Professor Nophar Geifman, said: 

“The foods that you like or dislike appear to be directly linked to your health. If your favorite foods are cakes, sweets, and sugary drinks, our study’s results suggest that this may have negative effects on your health. We found that the group with a sweet tooth is 31% more likely to have depression. Additionally, this group had higher rates of diabetes and vascular heart conditions compared to the other two groups.”

“Importantly, by utilizing data-driven artificial intelligence methods, we managed to categorize individuals based on their food preferences. These categories have significant associations with health outcomes and biological markers.”

“Processed sugar is a significant part of many people’s diets. These results provide further evidence that, as a society, we should be mindful of what we eat. It’s important to stress that we’re not trying to tell people what to do; our job is simply to inform.”

The researchers also looked at differences between the three groups in standard blood biochemistry tests.  

Professor Geifman continues: 

“In the sweet tooth group, they had higher levels of C reactive protein, which is a marker for inflammation. Their blood results also show higher levels of glucose and poor lipid profiles, which is a strong warning sign for diabetes and heart disease.” 

Conversely, the health-conscious group, which also had higher dietary fibre intake, had lower risks for heart failure, chronic kidney diseases and stroke, while the omnivore group had moderate health risks. 

According to the British Nutrition Foundation, on average, in the UK, between 9% to 12.5% of an individual’s calories come from free sugar – this is defined as sugar that is added to food or drink.  Biscuits, buns, cakes, pastries and fruit pies are the biggest single contributors for adults, but together, sugary soft drinks and alcoholic drinks contribute the most to free sugar intake. 

Risk of stroke increases with insulin resistance, study suggests


A study of more than 100,000 people with type 2 diabetes (T2D), presented at the annual meeting of the European Association for the Study of Diabetes (EASD), held online this year, found that insulin resistance is associated with stroke.

The higher the insulin resistance, the greater the risk of stroke, the research, from Dr Alexander Zabala and colleagues at the Karolinska Institute and researchers at Gothenburg University and the National Diabetes Registry in Sweden, found.

Insulin resistance – when the body’s cells don’t respond properly to insulin and can’t easily take up glucose from blood – is a key feature of T2D and levels vary from patient to patient.

Dr Zabala used estimated glucose disposal rate (eGDR) as a measure of insulin resistance.

eGDR has previously been shown to be a good proxy for insulin resistance and is calculated using a formula that factors in a patient’s waist circumference, HbA1c (average blood sugar level) and whether they have high blood pressure.

Health records were used to calculate the eGDR of 104,697 T2D patients in Sweden.  The participants had an average age of 63 and 44.5% were female.

They were followed up for an average of 5.6 years, during which 4,201 (4%) had a stroke. 

Analysis revealed that the higher a person’s insulin resistance, the greater their chance of having a stroke.  Those with the lowest insulin resistance (the highest eGDR) were 40% less likely to have a stroke than those with the highest insulin resistance.

Age, cholesterol levels, smoking, heart conditions and other traditional risk factors for stroke were all adjusted for.

The study also found that higher insulin resistance was linked to a higher risk of death after a stroke. Those with the lowest resistance were 28 per less likely to die during the follow-up period than those with the most severe insulin resistance.

Further analysis showed high blood pressure to be more strongly linked to stroke than waist circumference or HbA1c.

The study’s authors conclude: “We found that in individuals with type 2 diabetes, a low eGDR, a simple measure of insulin resistance, was associated with an increased risk of stroke and mortality.”

Dr Zabala adds: “eGDR could be used to help T2D patients better understand and manage their risk of stroke and death. 

“It could also be of importance in research.  In this era of personalised medicine, better stratification of type 2 diabetes patients will help optimise clinical trials and further vital research into treatment, diagnosis, care and prevention.”

More than one million stroke survivors live in fear of having another stroke

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More than one million(i) stroke survivors (89%) live in fear of having another stroke and are scared to go out alone (79%), leaving them afraid for their recovery (79%) in the aftermath of their stroke, according to a leading national charity. The Stroke Association’s startling new findings(ii) show how people’s recoveries are under threat from fear itself.

The charity’s latest research (of over 1,000 stroke survivors) also reveals the hidden barriers that people can face after stroke, often too scared to talk to anyone about: 

  • One in five (20%) stroke survivors said they kept their fears to themselves and didn’t talk to anyone
  • Over a third (37%) of these stroke survivors said they didn’t want to worry anyone; they were too afraid (27%) or didn’t want to sound stupid (26%) by talking about their fears.

On top of dealing with these fears and concerns, the study also shows that many stroke survivors are facing their recovery alone. This leads to a bleak attitude to recovery with almost nine in ten (88%) survivors afraid they won’t get better and four out of five (80%) fearing they would get sent to a care home when they first had their stroke. Fear prevents people from getting out and about and meeting others, two of the key factors that stroke survivors have said are integral to their recovery.

Juliet Bouverie, Chief Executive of the Stroke Association, said: “These stats are truly shocking. I am heart-broken to hear that stroke survivors felt they couldn’t speak to those closest to them about their biggest worries and fears. When you live in isolation, too afraid to leave the house and are unable to ask for help, your motivation can disappear, and can leave you in a very bad place emotionally – feeling like a prisoner in your own home.

“It takes a team to rebuild lives after stroke. When stroke strikes, part of your brain shuts down, and so does a part of you. Recovery is tough, but with the right specialist support, the brain can adapt after stroke. I’ve heard countless stories, and know countless people who, after many years continue to make remarkable recoveries. The first step to eliminating fear is to ask for help and support. If you are a stroke survivor, this could mean speaking to your doctor or social worker to get some answers. If you know a stroke survivor, reach out, ask them how they’re feeling. No one should have to live their life in constant fear.”

The Stroke Association’s research also found that:

  • Only 18% of stroke survivors were confident that they would get enough support to make a good recovery
  • 87% of stroke survivors said they feared losing their independence
  • 81% of stroke survivors said they were afraid they wouldn’t be able to look after their children or parents.

Juliet continues: “I was horrified to find out that there are still many people who feel helpless. People are missing out on the life they could have – this must change. Don’t be afraid to ask questions about your health. We want everyone to know that you can rebuild your life after stroke. Every stroke is different and so is every recovery. It can take years to adjust to a new normal.

“The Stroke Association’s Helpline is for everyone affected by stroke. There are no stupid questions. If you are worried about anything, call 0303 3033 100 and get support from one of our trained helpline staff.”

For more information about Rebuilding Lives or about stroke, visitwww.stroke.org.uk/rebuildinglives.

What To Do If Someone Has A Stroke – Signs & Symptoms –




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Find out more about what to do if someone is having a stroke and learn more about what a stroke is, causes, signs & symptoms here:

A St John Ambulance trainer demonstrates what to look for if someone is having a stroke and what to do to help.