Fecal Transplant for Multiple Sclerosis Explained by Neurologist

Fecal microbiota transplant - Wikipedia


Given the strong evidence for the role of the microbiome in autoimmune diseases, fecal transplant from a donor has been proposed as a potential treatment of MS. This video looks at the theory behind fecal microbiota transplant and the published data in MS.


What do the NHS and other healthcare professionals have to say about the “poo transplant” for autism

Image result for youtube fecal transplant

“Autism symptoms can be reduced 50% in children who received faecal transplants,” reports the Mail Online.

A new US study involving 18 children with autism spectrum disorder (ASD) found an improvement in digestive and autism symptoms 2 years after receiving a faecal transplant.

Eight children no longer fitted the criteria for a diagnosis of ASD and there was a 58% reduction in gut symptoms overall.

Faecal transplants, originally designed to treat C. diff infections, involves receiving a transplant of gut microbes taken from a donor with a healthy makeup of gut bacteria.

This procedure has been found to improve gut health and digestive symptoms.

While ASD is mainly associated with behavioural symptoms, people with ASD can also experience digestive symptoms such as diarrhoea and constipation.

Research suggests improving gut health could improve the children’s ASD symptoms.

These are encouraging results, but this is very early-stage research involving just a small sample of children.

Though no adverse effects were reported, the safety of the procedure would need to be determined in a much larger trial.

There’s also the possibility that the results were due to the placebo effect, so a randomised controlled trial is needed to make sure that the treatment works.

Where did the story come from?

The study was carried out by researchers from Arizona State University, Integrative Developmental Pediatrics and Northern Arizona University, all in the US.

It was funded by Finch Therapeutics and the Arizona Board of Regents.

The study was published in the peer-reviewed journal Scientific Reports on an open access basis, so it can be read for free online.

The Mail Online reported the study accurately, included expert opinions and explained that a much bigger trial would be needed before the treatment could be approved.

What kind of research was this?

This was a follow-up study of a case series. This type of study takes a small group of people with a condition, gives them all the same treatment and follows them up over time.

Any improvements or side effects might be a result of the treatment, but a randomised controlled trial would be needed to verify the results.

What did the research involve?

The researchers followed up 18 children with ASD who’d previously been given a course of healthy donor gut bacteria.

The children ranged in age from 7 to 17.

Prior to the original study they’d suffered from moderate to severe gastrointestinal problems, such as abdominal pain, indigestion, diarrhoea and constipation, since they were infants.

In the original study, the children were given:

  • a 2-week course of vancomycin, an antibiotic to reduce unhealthy bacteria in the gut
  • MoviPrep, a strong laxative to remove any traces of vancomycin and bacteria
  • a proton-pump inhibitor, which reduces the amount of acid in the stomach in the hope that this would increase the survival rate of the donor bacteria
  • healthy gut bacteria from a donor (standardised human gut microbiota) for 7 to 8 weeks

Two years later, the children and their parents completed various assessments of their autism and gut symptoms.

Sixteen children provided a stool sample to measure their gut bacteria.

What were the basic results?

There was a 58% reduction in gut symptoms according to the Gastrointestinal Symptom Rating Scale (GSRS), a checklist that looks at symptoms such as constipation, diarrhoea and bloating.

Abnormal stools (such as watery or hard stools) occurred less frequently, on a quarter fewer days than before, and most children had a wider range of gut bacteria.

According to the Childhood Autism Rating Scale (CARS):

  • the severity of ASD was 47% lower
  • 3 children were rated as severe, compared with 15 before the treatment
  • 7 were rated as mild-moderate
  • 8 were below the cut-off level for diagnosis of an ASD

Parent-rated assessments also showed improvements:

  • 8 of the children were rated as severe on the Social Responsiveness Scale (SRS), compared with 16 before the treatment
  • scores on the Aberrant Behavior Checklist (ABC) were 35% lower

Children with improvements in gut symptoms were more likely to have also had improvements in symptoms of ASD.

How did the researchers interpret the results?

The researchers concluded that: “These encouraging observations demonstrate that the intensive MTT [microbiota transfer therapy] intervention is a promising therapy for treating children with ASD who have GI problems.”

They said they “recommend future research including double-blind, placebo-controlled randomised trials with a larger cohort.”

Conclusion

This small study shows promise for this treatment protocol, but as the researchers are quick to point out, the results need to be verified in a much larger placebo-controlled trial.

At this early stage, we do not know whether the improvements observed were a result of the placebo effect, as the study was not blinded.

In addition, it could be 1 or a few aspects of the treatment protocol that made the difference, rather than all 4 steps. For example, the stomach acid suppressant may have been the key factor.

Though the researchers excluded children with specific gut diagnoses, such as ulcerative colitis, they did not perform any investigations.

This means there may have been a wide variety in the causes among the children studied, which could explain why some improved and others did not.

Previous studies have shown an association between gut symptoms and ASD, but this is not the case for all children with ASD.

So even if the treatment is shown to be effective, it may just be for a select group of children.

The results of the study could also have been affected by the fact 12 of the children had changed their usual medication, supplements or diet during the course of the 2-year follow-up.

Analysis by Bazian 
Edited by NHS Website

Autism symptoms reduced nearly 50% two years after fecal transplant – Could this be true?

Recent research suggests our gut microbiomes affect brain communication and neurological health. Worldwide, interest is growing in the idea that changes in normal gut microbiota may be responsible for triggering various conditions. At ASU, a research team is exploring using the microbiome to treat autism symptoms.
Image credit: Shireen Dooling

According to the Centers for Disease Control and Prevention, about one in every 59 children in the U.S. is diagnosed with autism, up from one in every 150 in 2000. They report that “about half a million people on the autism spectrum will become adults over the next decade, a swelling tide for which the country is unprepared.”

The apparent rise in autism spectrum disorder (ASD) and its stubborn resistance to treatment has spurred a legion of researchers to enter the field and explore the disability in innovative ways.

Currently, effective treatments for ASD include behavioral therapy, speech and social therapy, psychiatric medications, and dietary and nutritional approaches. However, no medical treatments have been approved to treat core symptoms of ASD such as social communication difficulties and repetitive behaviors.

One promising avenue of autism research involves the gut microbiome, which is the collection of microbes that lives in our intestines and helps us in many ways including digestion of our food, training our immune system and preventing overgrowth of harmful bacteria. Recent research suggests our gut microbiomes also affect brain communication and neurological health. Worldwide, interest is growing in the idea that changes in normal gut microbiota may be responsible for triggering a vast range of diseases.

In a new study, “Long-term benefit of Microbiota Transfer Therapy in Autism Symptoms and Gut Microbiota,” published in Scientific Reports, Arizona State University researchers Rosa Krajmalnik-Brown, Ph.D., James Adams, Ph.D, and lead author Dae-Wook Kang, Ph.D, demonstrate long-term beneficial effects for children diagnosed with ASD through a revolutionary technique known as Microbiota Transfer Therapy (MTT), a special type of fecal transplant originally pioneered by Dr. Thomas Borody, an Australian gastroenterologist. Remarkably, improvements in gut health and autism symptoms appear to persist long after treatment.

At two years post-treatment, most of the initial improvements in gut symptoms remained. In addition, parents reported a slow steady reduction of ASD symptoms during treatment and over the next two years. A professional evaluator found a 45% reduction in core ASD symptoms (language, social interaction and behavior) at two years post-treatment compared to before treatment began.

“We are finding a very strong connection between the microbes that live in our intestines and signals that travel to the brain,” said Krajmalnik-Brown, a professor at the Biodesign Swette Center for Environmental Biotechnology at the Biodesign Institute and ASU’s School for Sustainable Engineering and the Built Environment. “Two years later, the children are doing even better, which is amazing.”

“Many kids with autism have gastrointestinal problems, and some studies, including ours, have found that those children also have worse autism-related symptoms,” said Krajmalnik-Brown. “In many cases, when you are able to treat those gastrointestinal problems, their behavior improves.”

Roughly 30-50% of all people with autism have chronic gastrointestinal (GI) problems, primarily constipation and/or diarrhea that can last for many years. That chronic discomfort and pain can cause irritability, decreased attention and learning, and negatively impact behavior.

An earlier study with only vancomycin (an antibiotic) had found major temporary improvements in GI and autism symptoms, but the benefits were lost a few weeks after treatment stopped despite use of over-the-counter probiotics.

So, the question at hand was what’s going on in the gut, and how does it affect both physical and behavioral symptoms of autism, and how can we develop a long-lasting treatment?

Krajmalnik-Brown, Kang and Adams have shown that by transferring healthy microbiota to individuals lacking certain gut bacteria, it is possible to “donate” a more diverse set of bacteria into the patient and improve gut health.

In Australia, Fecal Microbiota Transplantation (FMT) was initially developed by Borody. At his Centre for Digestive Diseases in Sydney, Borody has overseen more than 18,000 FMTs for various disorders since 1987. He pioneered in Australia the use of FMT for colitis and Clostridium difficile infection, and was the first to use oral FMT to treat children with ASD. Only one dose of FMT is usually enough to cure C. Difficile infections, but his patients with autism were far harder to treat. He discovered that three months of daily FMT was required to treat his autism patients, but eventually resulted in significant improvements in both GI and autism symptoms.

Based on his experience with his patients, Borody led the design of the clinical treatment used at ASU for this study. The MTT approach involves 10 weeks of treatment, including pre-treatment with vancomycin, a bowel cleanse, a stomach acid suppressant, and fecal microbiota transfer daily for seven to eight weeks.

The initial open-label study, led by Krajmalnik-Brown and Adams, and published in the journal Microbiome in 2017, concluded that “this exploratory, extended-duration treatment protocol thus appears to be a promising approach to alter the gut microbiome and improve GI and behavioral symptoms of ASD. Improvements in GI symptoms, ASD symptoms, and the microbiome all persisted for at least eight weeks after treatment ended, suggesting a long-term impact.” The present study now shows the benefits are extended beyond eight weeks to at least two years post-treatment.

The ASU team compared differences in the microbiome of children with autism compared to typically developing children. At the start of the study, children with autism were found to have lower diversity in their respective gut microbes and were depleted of certain strains of helpful bacteria, such as Bifidobacteria and Prevotella. “Kids with autism are lacking important beneficial bacteria, and have fewer options in the bacterial menu of important functions that bacteria provide to the gut than typically developing kids,” Krajmalnik-Brown said.

FMT treatment substantially increased microbial diversity and the presence of helpful bacteria in the gut, such as Bifidobacteria and Prevotella. After two years, diversity was even higher and the presence of beneficial microbes remained.

“We originally hypothesized that our therapy would be efficient to transform the dysbiotic gut microbiome toward a healthy one. In our original paper in 2017, we reported an increase in gut diversity together with beneficial bacteria after MTT, and after two years, we observed diversity was even higher and the presence of beneficial microbes remained,” Kang said. He added that this may be one of the reasons for success in improving the gut health, but further mechanistic studies are warranted to define specific roles of gut microbes in the context of autism.

The work done at ASU is not only about treating patients but also about learning from the treatment in order to develop better formulations and optimize dosing.

“Understanding which microbes and chemicals produced by the microbes are driving these behavioral changes is at the heart of our work,” Krajmalnik-Brown said. The team’s new publication reports that the study demonstrated that two years after treatment stopped the participants still had an average of a 58% reduction in GI symptoms compared to baseline. In addition, the parents of most participants reported “a slow but steady improvement in core ASD symptoms.”

“Every family completed the study, and every family returned two years later for a follow-up evaluation,” said Adams, citing the families’ dedication to the research. “The treatment was generally well-tolerated with minimal adverse effects.”

“This is a world-first discovery that when we treated the gut bacteria in these children during our clinical trial two years ago to reset their microbiome with FMT, positive results are still continuing to be improving two years from the original treatments. I would call it the highest improvement in a cohort that anyone has achieved for autism symptoms,” said Borody.

Professional evaluation revealed a 45% decrease in ASD symptoms compared to baseline. Researchers note that although there may be some placebo effect, much of that effect appears to be real. At the start of the study, 83% of participants were rated as “severe” autism. At the end of the study, only 17% were “severe,” 39% were “mild/moderate,” and 44% were below the cut-off for mild ASD.

Greg Caporaso, at Northern Arizona University, a leading expert in microbiome data science and a co-author on these studies, helped to analyze the microbiome data to better understand bacterial changes as a result of MTT.

“Drs. Krajmalnik-Brown, Kang and I are excited about the results, but we want to caution the public that we need larger clinical trials for this to become an FDA-approved treatment,” said Adams. Professional expertise is required for safe and effective treatment.

MTT improves GI distress by introducing key strains of beneficial bacteria and helping to raise levels of biodiversity within the gut, boosting health overall.

Adams has both professional and personal reasons for doggedly pursuing ways to help children with autism because he knows the situation first-hand. His daughter was diagnosed with autism just before her third birthday. Adams, a President’s Professor at ASU’s School for Engineering of Matter, Transport and Energy, and the chair of Materials Sciences, is also president of the Autism Society of Greater Phoenix, the largest parent support group in Arizona.

“Dr. James Adams is the reason why I started working on autism,” Krajmalnik-Brown said. “I had the methods to do all of the measurements and assessments in the microbiome part of the work, and he had the autism knowledge.”

Adams recruited patients, supervised clinical work and ASD assessments, and guided the patients through the trials, and Krajmalnik-Brown led the microbiome evaluations and helped plan the study.

All of the participants in the study exhibited chronic GI symptoms from infancy, including chronic constipation and/or chronic diarrhea. The treatment benefits extended beyond their physical symptoms, even causing some parents to note how much their children’s behavior had improved over time.

“It is very unusual to see steady gradual improvement after the conclusion of any treatment,” said Adams. “We only conducted the long-term follow-up study after several families told us that their child was continuing to improve significantly.” Krajmalnik-Brown stated that the data suggests that the MTT intervention transformed the gut environment into a healthier status, leading to long-term benefit on both GI and ASD symptoms.

Adams said many of the participants in the trial shared common traits, including birth by C-section, reduced breastfeeding, increased antibiotics, and low fiber intake by the mother and child, all of which lead to limited biodiversity in their gut bacteria. Due to the open label nature of the study and the small sample size used, more research is needed in order to verify the usefulness of MTT as a therapeutic.

The initial study involved a “first-generation” estimate as to optimal dose and duration of treatment, and it was enough for 90% of the children to have substantial benefit. The team is now working on optimizing the dosing and duration to try to improve benefits even more, and to determine if booster doses may be needed in some cases.