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Fresh mango CREDIT National Mango Board
. As low fruit and vegetable consumption continues to contribute to diet-related chronic diseases like diabetes and heart disease, two new research studies find regular mango consumption may improve diets and help manage key risk factors that contribute to chronic disease.
Specifically, these new studies report findings in two areas: 1) mango consumption is associated with better overall diet quality and intake of nutrients that many children and adults lack at optimum levels, and 2) snacking on mangos may improve glucose control and reduce inflammation in contrast to other sweet snacks. With mangos consumed widely in global cuisines and 58% of Americans reporting snacking at least once a day in 20211, this new research provides added evidence that regularly consuming mangos may have health advantages and be relevant to cultural dietary preferences and current eating patterns.
Mango consumption associated with higher diet quality and better intakes of nutrients of concern in children and adults
A recent observational study found positive outcomes in nutrient intakes, diet quality, and weight-related health outcomes in individuals who consume mangos versus those who do not2. The study, published in Nutrients in January 2022, used United States National Health and Nutrition Examination Survey (NHANES) 2001-2018 data to compare the diets and nutrient intakes of mango consumers to people who did not consume mangos.
The study showed that children who regularly ate mango had higher intakes of immune-boosting vitamins A, C and B6, as well as fiber and potassium. Fiber and potassium are two of the four “nutrients of concern” as defined by the Dietary Guidelines for Americans, which means many Americans are not meeting recommendations for these. In adults, researchers found similar results, showing that mango consumption was associated with significantly greater daily intakes of fiber and potassium but also vitamins A, B12, C, E and folate, a vitamin critical during pregnancy and fetal development. For both children and adults, consuming mango was associated with a reduced intake in sodium and sugar, and for adults was associated with a reduced intake of cholesterol.
“We have known for a long time that there is a strong correlation between diet and chronic disease,” says Yanni Papanikolaou, researcher on the project. “This study reveals that both children and adults eating mangos tend to have significantly better diet quality overall along with higher intakes of fiber and potassium compared with those who don’t eat mangos. It is also important that mango fits into many diverse cuisines. Whole fruits are under consumed, and mango can encourage fruit consumption especially among growing diverse populations.”
Snacking on mangos associated with better glucose control and lower inflammation
In addition to these broad benefits of mango consumption, a separate pilot study, published in Nutrition, Metabolism & Cardiovascular Diseases in 2022 looked at mango as a snack and found that consuming whole mangos as a snack versus a control snack had better health outcomes in overweight and obese adults3. Given 97% of American adults consume snacks that contribute up to 24% of their daily energy intake4 this study sought to compare snacking on 100 calories of fresh mango daily to snacking on low-fat cookies that were equal in calories.
Twenty-seven adults participated in the study, all classified as overweight or obese based on Body Mass Index (BMI) and reported no known health conditions. Participants were given either mango or low-fat cookies as a snack while maintaining their usual diet and physical level for 12 weeks, and after a four-week wash-out period the alternating snack was given for another 12 weeks. Researchers measured the effects on glucose, insulin, lipid profiles, liver function enzymes and inflammation. At the end of the trial period, findings indicated that mango consumption improved glycemic control (an individual’s ability to manage blood glucose levels, an important factor in preventing and managing diabetes) and reduced inflammation.
Results showed there was no drop in blood glucose when participants snacked on low-fat cookies. However, when snacking on mangos there was a statiscally significant (p= 0.004) decrease in blood glucose levels at four weeks and again at 12 weeks, even though there was twice as much sugar, naturally occurring, in the mangos compared to the cookies. Researchers also observed statistically significant improvements to inflammation markers, total anti-oxidant capacity (TAC) and C-reactive protein (CRP), when snacking on mangos. TAC is a measurement of overall antioxidant capacity, or how well foods can prevent oxidation in cells. CRP is biomarker used to measure inflammation in the body. The research suggest that the antioxidants abundant in mangos offered more protection against inflammation compared to the cookies.
“The findings of this study show that antioxidants, fiber and polyphenols abundant in mango may help to offset sugar consumption and aide in glucose control. Antioxidants may also offer protection against inflammation” says Dr. Mee Young Hong, lead investigator on the study and Professor in the School of Exercise and Nutritional Sciences at San Diego State University. “Further research is needed but the initial findings are encouraging for people who enjoy sweet snacks.”
Some limitations in this study include sample size, using only one dose of mango, and measuring effects on participants without any pre-existing conditions. Further research should explore optimal dose of mango and examine long-term effects of mango consumption on those with metabolic conditions. It would also be of benefit to compare mango to a fiber-matched control snack to distinguish the effects of fiber versus the bioactive compounds in mangos.
With only 99 calories and over 20 different vitamins and minerals, a 1 cup serving of mango is nutrient-dense, making it a superfood. Because mangos are widely consumed in cultures around the world and United States, research into their health benefits contributes to a better understanding of their place in a healthy diet.
Both studies were supported by funds from the National Mango Board.
Anders Gudiksen and one of the participants CREDIT Anders Gudiksen, University of Copenhagen
Fat tissue plays an important role in human health. However, our fat tissue loses function as we age, which can lead to type 2 diabetes, obesity, cancer and other ailments. High levels of lifelong exercise seem to counteract this deterioration. This, according to research at the University of Copenhagen, where biologists studied the link between aging, exercise and fat tissue function in Danish men.
How well does your fat function? It isn’t a question that one gets asked very often. Nonetheless, research in recent years suggests that the function of our fat tissue, or adipose tissue, is central to why our bodies decay with age, and strongly linked to human diseases like diabetes 2, cancer as obesity often develop and fat cells undergo functional changes as we get older. Thus, overall health is not just influenced by the amount of fat we bear, but about how well our fat tissue functions.
A new University of Copenhagen study demonstrates that even though our fatty tissue loses important function with age, a high volume of exercise can have a significant impact for the better.
“Overall health is closely linked with how well our fat tissue functions. In the past, we regarded fat as an energy depot. In fact, fat is an organ that interacts with other organs and can optimize metabolic function. Among other things, fat tissue releases substances that affect muscle and brain metabolism when we feel hungry and much more. So, it’s important that fat tissue works the way it should,” explains Assistant Professor Anders Gudiksen of the University of Copenhagen’s Department of Biology.
Gudiksen and a group of colleagues looked at the role of age and physical training in maintaining fat tissue function. Specifically, they studied mitochondria, the tiny power plants within fat cells. Mitochondria convert calories from food to supply cells with energy. To maintain the life processes within cells, they need to function optimally.
The researchers compared mitochondrial performance across a range of young and older untrained, moderately trained and highly exercise trained Danish men. The results demonstrate that the ability of mitochondria to respire – i.e., produce energy – decreases with age, regardless of how much a person exercises. However, Anders Gudiksen explains:
“Although mitochondrial function decreases with age, we can see that a high level of lifelong exercise exerts a powerful compensatory effect. In the group of well-trained older men, fat cells are able to respire more than twice as much as in untrained older men.”
Just as a car engine produces waste when converting chemical to usable energy, so do mitochondria. Mitochondrial waste comes in the form of oxygen free radicals, known as ROS (Reactive Oxygen Species). ROS that isn’t eliminated damages cells and the current theory is that elevated ROS can lead to a wide range of diseases including cancer, diabetes, cardiovascular disease and Alzheimer’s. Therefore, the regulation of ROS is important.
“The group of older people who train most form less ROS and maintain functionality to eliminate it. Indeed, their mitochondria are better at managing waste produced in fat cells, which results in less damage. Therefore, exercise has a large effect on maintaining the health of fat tissue, and thereby probably keeping certain diseases at bay as well,” says Gudiksen.
The researchers can also see that the older participants who exercised most throughout life have more mitochondria, allowing for more respiration and, among other things, an ability to release more of the fat-related hormones important for the body’s energy balance.
‘Our results show that you can actually train your fat tissue to a very high degree – but that you needn’t cycle 200km a week to achieve a positive effect. What you shouldn´t do, is do nothing at all,” concludes Anders Gudiksen, who hopes that the research world will focus more on what people can do to maintain the health of their fatty tissue.
The next step for the UCPH researchers will be to investigate where exactly cellular damage occurs when people don’t exercise and what impact this has on the body as a whole over time. Concurrently, the researchers are exploring ways to pharmacologically manipulate the mechanism in the mitochondria that converts calories into heat instead of depositing calories as fat, in turn lowering the production of the harmful oxygen radicals.
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