Researchers from Michigan State University and South Shore Hospital in Massachusetts have discovered a link between two common diabetes medications – insulin and metformin – found in the fluid from diabetic foot ulcers, which could enhance their healing.
While analyzing wound exudate (the fluid the body moves and secretes to the site of an injury), researchers discovered the presence of metformin in patients who take the drug orally.
The researchers investigated the connection between metformin and insulin. They discovered that in patients who use both insulin injections and oral metformin, the concentration of metformin in wounds significantly rises. Previously, it was thought that there was no interaction between insulin and metformin.
The team’s findings may be immediately relevant to healthcare professionals treating patients with diabetic foot ulcers and biotech developers of wound dressings.
New research being presented at the annual meeting of the European Association for the Study of Diabetes (EASD) in Madrid, Spain (9-13 September) suggests that weight loss interventions could reduce the risk of severe cases of flu and other infections in people with diabetes.
The study by Rhian Hopkins and Ethan de Villiers at the University of Exeter Medical School in Exeter, UK, found evidence suggesting that a higher BMI is associated with severe infections.
In contrast, there was no evidence that mild hyperglycemia contributes to the likelihood of a severe infection.
Hopkins stated, “Up to one in three hospitalizations among people with diabetes are due to infections, and individuals with diabetes are twice as likely to be hospitalized with infections compared to the general population. They also face a high risk of readmission.”
Previous studies have found that higher BMI and poor blood sugar control are associated with severe infections. However, these studies have been observational and thus haven’t been able to prove causal links.
“If one or both of these factors can be shown to be causal, it may be possible to design interventions to lower the risk of severe infections in those at high risk, such as people with diabetes.”
The recent study utilized data from the UK Biobank, which contains medical and genetic information on approximately 500,000 individuals in the UK. The study aimed to investigate the impact of elevated BMI and inadequate blood sugar regulation on the likelihood of being hospitalized due to bacterial and viral infections.
A higher BMI was found to be associated with hospitalisation with infections. Similarly, every five-point increase in BMI was associated with a 32% increase in the likelihood a severe viral infection.
An association between mild hyperglycemia and severe infections was found. The likelihood of hospitalization due to bacterial infection increased by 32% per 10mmol/mol rise in HbA1c, a measure of blood sugar levels.
This suggested that a higher BMI is one of the causes of severe bacterial and viral infections.
However, mild hyperglycaemia did not appear to cause severe infections.
Although the study didn’t focus on individuals with diabetes, Ms Hopkins says that, given their vulnerability to infections, the results may be particularly relevant to them.
She adds: “Infections are a significant cause of death and ill health, particularly in people with diabetes. Anyone admitted to hospital with a severe infection is also at high risk of being admitted again with another. However, we currently have few practical ways to prevent this.
“This study demonstrates that higher BMI is a cause of hospital admission with infection. Clinicians could discuss weight loss options for people with a high BMI at risk of severe infections and readmission to hospital for infection.”
“While this message may be particularly relevant to people with diabetes, it applies more widely.”
Further research is needed to determine if more severe hyperglycaemia is a cause of severe infections.
Supporting a loved one with a chronic health condition can be a complex and emotional journey. It often requires a thoughtful approach that balances compassion, understanding, and practical assistance. Every individual’s needs are different, and finding unique ways to provide care can significantly impact their overall well-being. Below, Patient Talk explains how exploring creative and personalized support methods can help them manage their challenges while feeling valued and understood.
Consistent Communication and Genuine Listening
Staying connected regularly is one of the simplest and most meaningful things you can do. Checking in often, either through a phone call or in person, reassures them that you care. When they share their thoughts or challenges, listen attentively without interrupting. Let them know that their feelings matter, and validate their emotions to ensure they feel understood and respected.
Build a Reliable Support System
Helping your loved one form a support network is crucial in managing a long-term health condition. This could involve connecting them with nearby support groups, online communities, or local assistance services. A solid support system of friends, family, and professionals can provide emotional strength, advice, and practical help. The presence of others who understand their situation can be a great source of comfort.
Safe and Natural Pain Relief Alternatives
Several alternative approaches can help ease chronic pain. Consider introducing these safe, natural treatments:
Acupuncture: A traditional method that helps relieve pain by targeting pressure points.
Massage Therapy: Regular massages can alleviate muscle tightness and improve overall relaxation.
Cold Therapy: This involves using cold compresses or ice packs to reduce inflammation and ease discomfort.
THCa: A non-intoxicating compound from cannabis that is being explored for its potential to reduce pain and inflammation—this could be a good choice for those looking for alternative, non-psychoactive pain relief.
Structure a Balanced Health Routine
A well-planned schedule can bring order and ease to the day-to-day challenges of chronic illness. Assisting your loved one in organizing their appointments, medications, and daily activities can reduce their stress. Be sure to include periods for rest, relaxation, and hobbies they enjoy. A structured but flexible routine ensures their health needs are met without overwhelming them.
Career Inspiration Through Caregiving
Helping a loved one manage a chronic condition can lead to discovering new career paths in caregiving or healthcare. If you’re already a nurse, this experience may motivate you to enhance your expertise and complete your RN-to-BSN online, boosting your patient care capabilities. Online education options offer the flexibility to further your career while continuing to care for your loved one. This allows you to pursue professional growth without compromising your responsibilities.
Create Thoughtful Care Packages
One unique way to show support is by putting together personalized care packages. These could include items specifically chosen to bring comfort, such as therapeutic teas, cozy blankets, or lotions for relaxation. Incorporating some of their favorite snacks or entertainment, like books or puzzles, adds a personal touch. Tailoring these packages to their preferences shows a deep understanding of their needs and offers them something to look forward to.
Inspire Creativity for Emotional Wellness
Encouraging creative outlets can be an effective way to uplift your loved one emotionally. Activities like painting, playing music, or journaling provide a safe space for expressing feelings and reducing stress. These creative practices can help divert attention from physical discomfort while boosting mental well-being. Support their interest in these outlets to foster emotional resilience and personal growth.
Use Technology for Simplified Health Management
Integrating technology into their daily routine can make managing their health less overwhelming. Apps that track medications, monitor symptoms, or offer virtual healthcare services can be invaluable tools. These digital aids help your loved one stay organized and informed, reducing the likelihood of missing important tasks or appointments. By incorporating these resources, they can manage their condition more independently and effectively.
Caring for someone with a chronic condition is an ongoing process that evolves as their needs change. By incorporating thoughtful, personalized actions into your care approach, you can provide meaningful support that positively impacts their physical and emotional health. Each small step can improve their quality of life, reminding them they are not alone on this journey. Your efforts today can foster a deeper connection and provide lasting comfort to your loved one.
If you enjoyed this article, you can find more helpful content at PatientTalk.org!
The price of multiple sclerosis drugs is astronomical and rapidly rising. But some drugs are now off-patent, and generic or biosimilar formulations offer new, cheaper alternatives. But are they just as good? This video takes a look at drugs such as glatiramer acetate (copaxone/glatopa), tecfidera, gilenya, aubagio, and tysabri and their alternative formulations.
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