The pervasiveness of inflammation foods in today’s diet

Anti-inflammatory foods can combat disease, researcher says
Anti-inflammatory foods can combat disease, researcher says

Almost 60% of Americans have pro-inflammatory diets, increasing the risk of health issues such as heart disease and cancer, according to a recent Omega 3 for chronic pain, by Dr Andrea Furlanstudy utilizing a tool designed to assess inflammation in the diet.


The study also found that specific populations, including Black Americans, men, and people with lower incomes, were more likely to consume a diet high in pro-inflammatory foods.

“Overall, 57% of U.S. adults have a pro-inflammatory diet and that number was higher for Black Americans, men, younger adults and people with lower education and income,” said lead author Rachel Meadows, visiting faculty in The Ohio State University’s College of Public Health.

The research team used the dietary inflammatory index, a tool developed a decade ago that includes 45 dietary components to examine the diets of more than 34,500 adults included in the 2005–2018 National Health and Nutrition Examination Survey. 

Based on self-reported diets, they used the tool to assign inflammation values ranging from −9 to 8, where 0 represents a neutral diet. About 34% of those in the study had anti-inflammatory diets, and the remaining 9% had neutral dietary inflammatory levels


Older dietary measures look at the intake of certain food groups (such as fruits, vegetables and dairy) or macronutrients (such as carbohydrates, proteins and fats) that align with national diet recommendations or certain diets like keto or paleo.

“But inflammation is an important element to consider and the overall balance of diet is most important,” Meadows said.

“Even if you’re eating enough fruits or vegetables, if you’re having too much alcohol or red meat, then your overall diet can still be pro-inflammatory.”

Meadows said she’s less interested in labeling foods as “bad” and more interested in thinking about anti-inflammatory foods as tools people can employ to boost health.

“There’s a potential here to think about positive interventions, such as adding more garlic, ginger, turmeric and green and black tea — which are all anti-inflammatory — to your diet,” she said.
“Moving toward a diet with less inflammation could have a positive impact on a number of chronic conditions, including diabetes, cardiovascular disease and even depression and other mental health conditions.”

Other examples of anti-inflammatory foods are mostly unprocessed including whole grains, green leafy vegetables (such as spinach), legumes (such as beans and lentils), fatty fish (such as salmon) and berries.
Challenges to eating a less inflammatory diet include poor access to fruits, vegetables and other foods that can contribute to better health — and even when those foods are available, they can sometimes be more costly, creating a barrier for those with low incomes, Meadows said.

Many people also have elevated chronic inflammation due to non-dietary factors including stress and adverse childhood experiences, she said.
“There are a lot of factors that contribute to chronic inflammation, and they all interact – even sleep is a key component. Diet can be used as a tool to combat that,” Meadows said.

Potential strategy against blood glucose drops in type 1 diabetes

Benrick and Rorsman

Anna Benrick and Patrik Rorsman, Sahlgrenska Academy at the University of Gothenburg, Credit Photo: University of Gothenburg.

New research suggests that inhibiting the hormone somatostatin could be a promising treatment approach for preventing severe drops in blood glucose levels in individuals with type 1 diabetes. A study conducted at the University of Gothenburg and other institutions has demonstrated the potential of this strategy to save lives.

When blood glucose levels decrease in healthy individuals, the pancreas releases a hormone called glucagon. This hormone prompts the liver to produce glucose, which helps to normalize the blood glucose levels. Glucagon has the opposite effect to insulin, another hormone that lowers blood glucose levels. Both insulin and glucagon are produced in the pancreas.

Individuals with type 1 diabetes have insufficient insulin as well as glucagon. When glucagon is not released during a drop in blood glucose, it results in dangerously low blood sugar levels, a condition that accounts for approximately 10% of all deaths in individuals with type 1 diabetes.

Restored ability to fend off drops in blood sugar

The latest study, published in the journal Nature Metabolism, introduces a potential new treatment approach for preventing dangerous blood sugar drops in individuals with type 1 diabetes. Patrik Rorsman, a leading researcher and Professor of Cellular Endocrinology at the Sahlgrenska Academy at the University of Gothenburg, as well as an active member of the University of Oxford, is one of the key contributors to this study.

The researchers examined groups of hormone-producing cells from the pancreas of humans and mice. They showed that in type 1 diabetes, these islets are unable to release glucagon when blood sugar is low. This is because the hormone somatostatin is released in greater amounts in type 1 diabetes and inhibits the release of glucagon.

Meanwhile, experiments showed that blocking somatostatin in mice with type 1 diabetes could restore the pancreas’s ability to release glucagon in the event of low blood sugar, thus preventing dangerously low blood sugar levels. The blocking was done pharmacologically.

Mapping of previously unknown signalling

Using genetically modified mice in which beta cells were activated by light, known as optogenetics, the interaction between different cell types in the pancreatic islets was also mapped: alpha cells that release glucagon, beta cells that release insulin and delta cells that release somatostatin.

The results provide an underlying explanation for how the reduced proportion of functioning beta cells in type 1 diabetes can be linked to the increased risk of blood sugar drops, something that has so far been unclear.

Anna Benrick is an Associate Professor of Physiology at the Sahlgrenska Academy at the University of Gothenburg and one of the co-authors.

“The new findings highlight an important and previously unknown role of electrical signaling that occurs through open cell connections between beta cells and delta cells,” she says. “If the electrical connections are lost, then the release of glucagon is reduced and the risk of a drop in blood pressure increases. The fact that this can be restored pharmacologically by blocking somatostatin opens up the possibility of preventing dangerous blood sugar drops in type 1 diabetes.”

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