The human body has co-evolved with these beneficial microbes, resulting in a mutually beneficial relationship that aids in food digestion and nutrient absorption. One key aspect of this relationship is the production of bile acids, which help break down fats.
Researchers have found that gut bacteria can modify bile acids to reduce bile production. However, the new study reveals that an enzyme produced by intestinal cells converts bile acids into a different form that promotes bile production and boosts fat metabolism.
Dr. David Artis from Weill Cornell Medicine explains that this dialogue between gut microbes and the body is vital for regulating bile acid production. This balancing act is crucial for maintaining healthy cholesterol levels and fat metabolism.
The study also found that boosting levels of these modified bile acids helped reduce fat accumulation in the liver and that increasing dietary fiber intake enhanced their production. These findings suggest potential treatment targets for metabolic disorders and highlight the importance of gut health in overall well-being.
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