In her keynote address at the inaugural Fibromyalgia Health & Wellbeing Summit (Dublin, 2018) Prof. Andrea Nicol provided historical perspectives on fibromyalgia and how recent rigorous and robust research methods have been used to determine what is felt to be the cause of fibromyalgia – central nervous system pain amplification. She also discussed well-described treatment options for fibromyalgia in addition to exploring emerging concepts and treatments for this challenging and complex pain syndrome.