Estimated 10 million lives a year could be put at risk because of the rise of drug-resistant infections by 2050

Porphyromonas gingivalis bacteria, 3D illustration. Anaerobic bacteria that cause periodontal disease, bacterial vaginosis, are probably associated with rheumatoid arthritis and esophageal cancer

·         99% of Brits are not aware of AMR’s full impact and only 11% see it as a serious threat to society

·         Antimicrobial resistance (AMR) contributes to more than 700,000 deaths each year

·         Estimated 10 million lives a year could be put at risk because of the rise of drug-resistant infections by 2050

Antimicrobial resistance (AMR) should be taken more seriously, yet more than 99% of the population are not fully aware of its impact. This is despite the outgoing UK Chief Medical Officer saying earlier this year that Superbugs “could kill us before climate change does”.

Superbugs, bacteria which develop resistance, already cause more than 700,000 deaths every year and the figure could rise to 10 million by 2050.

But, only 11% of Britons view AMR as a serious threat to society, ranking it below climate change (50%), religious conflicts (27%), and unemployment (23%), according to new research from Pfizer UK. 

Antibiotics have saved millions of lives since they were first discovered – but a world without antibiotics, where people die from infections which are currently treatable, could be closer than we think. Routine procedures, from c-sections to hip replacements, would become life-threatening – effectively any infection could become a death sentence, especially for those with a weakened immune system – for instance those undergoing chemotherapy treatment for cancer.[i] However, three-quarters of people asked don’t know or don’t believe that resistance could make caesareans too risky to perform.

Susan Rienow, Hospital Business Unit Lead, Pfizer UK: “The Pfizer UK survey, launched this World Antibiotics Awareness Week, demonstrates that more needs to be done to raise awareness of the dangers Superbugs pose to society. AMR is a complex problem with no single solution, but a major cultural shift is needed in how we view and use antibiotics. We need to work together to find solutions to ensure that future generations continue to benefit from these life-saving medicines.”

Antibiotic resistance occurs naturally, but misuse of antibiotics in humans and animals is accelerating the process. This includes using them for things like coughs and colds where they will have no effect.

AMR arises when the micro-organisms which cause infection (e.g. bacteria) survive exposure to a medicine that would normally kill them or stop their growth – creating the so-called Superbugs. 

If we do not act today, it is estimated that 10 million lives a year could be put at risk due to the rise of drug-resistant infections by 2050.[ii] 


[i] Teillant A, et al. Potential burden of antibiotic resistance on surgery and cancer chemotherapy antibiotic prophylaxis in the USA: a literature review and modelling study. The Lancet Journal of Infectious Diseases. 2015. DOI: https://doi.org/10.1016/S1473-3099(15)00270-4

[ii] World Health Organization. No Time to Wait: Securing the future from drug-resistant infections. Available at: https://www.who.int/antimicrobial-resistance/interagency-coordination-group/final-report/en/. Last accessed October 2019.

What is a Herpetic Whitlow and how can it be treated?




Herpetic whitlow

Herpetic whitlow

 

A herpetic whitlow, or whitlow finger, is an abscess of the end of the finger caused by infection with the herpes simplex virus (the “cold sore virus”).




 

It usually affects the fleshy area of the fingertip.

What are the symptoms?

The fingertip suddenly becomes red, swollen and extremely painful.

Small white blisters develop underneath the skin of the finger, which may break to release fluid, eventually crusting over.

What’s the cause?

There are two types of herpes simplex virus (HSV), type 1 and type 2.

Both HSV-1 and HSV-2 can cause a herpetic whitlow. These viruses can also cause cold sores and genital herpes.

A herpetic whitlow can develop as a secondary infection if you already have a cold sore or genital herpes and you touch the sore area of skin, transferring the virus from your mouth or genitals to your finger.

It can also develop if you touch the sore or blister of another infected person.

You’re at greater risk of becoming infected if you have a weakened immune system.




How is it treated?

Antivirals

A herpetic whitlow may be treated with an antiviral drug such as aciclovir.

You may be prescribed a five or seven day course of 200mg aciclovir to take five times a day or 400mg to take three times a day.

But this is only worth taking if you start the treatment within 48 hours of symptoms starting. Using an antiviral after this initial period is unlikely to have any effect.

Antiviral drugs may help to heal a herpetic whitlow, but they do not get rid of the herpes simplex virus or prevent future outbreaks of herpes simplex viral infection.

A whitlow will heal without an antiviral drug within two to three weeks. Antiviral treatment may:

reduce the time taken for the abscess to heal

reduce your risk of a secondary bacterial infection

reduce your risk of the herpes simplex virus spreading to other parts of the body

Caring for the whitlow at home

You should cover the whitlow with a light dressing so the infection doesn’t spread any further.

Avoid wearing contact lenses until the infection has healed, to stop the virus spreading to your eyes.

You can take an over-the-counter painkiller such as paracetamol or ibuprofen for pain relief.

Do not attempt to drain the fluid, as this may cause the virus to spread or cause a bacterial infection.

Will it come back?

The herpes virus remains dormant (inactive) in nerve cells and may reactivate at a later date, sometimes following stress or an illness. This can result in another whitlow at the same site as the first one

If a whitlow does return, it can be treated in the same way, with an antiviral drug.

If the whitlow returns often, the antiviral drug can be given for long periods of time (years) to reduce the number of times it comes back. This suppressive antiviral treatment will also reduce both the severity of the whitlow and the length of time it takes to heal.

Scabies – find out the signs and symptoms here.




Scabies

Scabies

[Original article on NHS Choices website]

 

Scabies is a contagious skin condition caused by tiny mites that burrow into the skin.

The main symptom of scabies is intense itching that’s worse at night. It also causes a skin rash on areas where the mites have burrowed.




Read more about the symptoms of scabies.

Scabies mites

Scabies mites are called Sarcoptes scabiei. They feed using their mouths and front legs to burrow into the outer layer of skin (epidermis), where they lay eggs.

After three to four days, the baby mites (larvae) hatch and move to the surface of the skin, where they mature into adults.

Scabies like warm places, such as skin folds, between the fingers, under fingernails, or around the buttock or breast creases. They can also hide under watch straps, bracelets or rings.

Read more about the life cycle of the scabies mite.

How scabies is spread

Scabies is usually spread through prolonged periods of skin-to-skin contact with an infected person, or through sexual contact.

It’s also possible – but rare – for scabies to be passed on by sharing clothing, towels and bedding with someone who’s infected.

It can take up to eight weeks for the symptoms of scabies to appear after the initial infection. This is known as the incubation period.

Read more about the causes of scabies.

Scabies outbreaks

Scabies is widespread in densely populated areas with limited access to medical care, and is most common in the following tropical and subtropical areas:

Africa

Central and South America

northern and central Australia

Caribbean Islands

India

southeast Asia

In developed countries, scabies outbreaks can sometimes occur in places where there are lots of people, such as schools, nurseries and care homes.




In the UK, most outbreaks of scabies occur in the winter. This may be because people tend to spend more time indoors and closer to each other at this time of year.

It’s difficult to know exactly how many cases of scabies there are in the UK. This is because many people don’t visit their GP and treat the condition with non-prescription medicines.

Treating scabies

Visit your GP if you think you have scabies. It’s not usually a serious condition, but it does need to be treated.

The two most widely used treatments for scabies are permethrin cream and malathion lotion (brand name Derbac M). Both medications contain insecticides that kill the scabies mite.

Permethrin 5% cream is usually recommended as the first treatment. Malathion 0.5% lotion is used if permethrin is ineffective.

If your partner has been diagnosed with genital scabies, to avoid reinfection you should visit your nearest sexual health clinic so you can be checked and, if necessary, treated.

Avoid having sex and other forms of close bodily contact until both you and your partner have completed the full course of treatment.

Read more about diagnosing scabies and treating scabies.

Complications of scabies

Scabies can sometimes lead to a secondary skin infection if your skin becomes irritated and inflamed through excessive itching.

Crusted scabies is a rare but more severe form of scabies, where a large number of mites are in the skin. This can develop in older people and those with a lowered immunity.

Read more about complications of scabies.

New Treatment for a New Approach in HIV Care

ViiV Healthcare today announces the marketing authorisation of a new treatment for HIV patients which will see the first once daily, single-tablet two-drug regimen authorised in the UK for those starting HIV treatment as well as those currently on treatment.

Treatments for HIV have progressed radically over the past few decades: ViiV’s latest  drug, ‘Dovato’ (dolutegravir/lamivudine) is a two-drug regimen which is proven to work as well as traditional three-drug regimens with no cases of resistance through 48 weeks. This means that people living with HIV may be able to take fewer drugs whilst having the same efficacy outcomes.

People with HIV now live longer, fuller lives than previous decades, yet, a lack of awareness often leads to misconceptions meaning people can fear and judge those living with HIV.

Myths surrounding HIV often involve misunderstanding around the quality of life lived by those following a diagnosis, which has changed entirely over the past few decades. Those living with HIV have access to much bigger support networks than at the start of the epidemic in the 1980’s.

The ‘HIV Has Changed’ campaign aims to highlight further these vast differences in both treatment and support that those living with HIV experience nowadays. The message of ‘can’t pass it on’ based on the evidence that people on effective HIV treatment with an undetectable viral load can’t pass on the virus to their sexual partners  encapsulates exactly how far everything has come.

Tropical Diseases: Preparation And Prevention

Earth’s tropical regions contain some of the most beautiful sites on the planet, but also some of the most virulent diseases that infect humans. Today, over one billion people around the world are affected by tropical diseases. Medical professionals are sorely needed in tropical countries to provide basic medical services to the world’s poorest and most vulnerable. Those who commit to serving in this way must be prepared, as there are some common tropical diseases with which they may come into contact. 

Three Common Diseases To Consider: Symptoms And Transmission

While there are countless diseases in the tropics, three in particular warrant additional focus and preparation before one visits the region to assist in a medical capacity.

Dengue Fever – This disease is a significant danger to people living in tropical regions – approximately 1/3 of the world’s population. As a mosquito-borne disease, dengue fever can best be prevented by disrupting or destroying mosquito colonies. On an individual basis, travelers should consistently use mosquito repellents to reduce exposure. Remain alert if you are in areas with nearby stagnant water, and regularly check for signs of mosquito bites.

Once contracted, symptoms of the disease generally present within 8-14 days. Fortunately, most people infected with the virus will only face mild symptoms, including a fever and rash. For about 5% of the population, however, the disease may cause hemorrhage, fluid accumulation in the chest, and blood supply issues, potentially leading to fatality. This risk is highest in those previously infected with the disease.

Rabies – Rabies is a worldwide disease, so its occurrence in the tropics is no surprise. It is transmitted by direct contact with infected saliva, generally through a bite. Small animals, including bats, dogs, and rodents, all pose a significant risk to humans. Avoiding transmission involves being aware of abnormal behavior; if an animal is unusually aggressive or fearless, there is a significant risk that they are infected. As direct contact is the only means of transmission, there is no other way to prevent transmission than simply avoiding infected animals.

The disease may incubate for 1-3 months after contraction before presenting symptoms. While there is a 99+% mortality rate once symptoms present, vaccination is often still effective, even if administered after infection, so long as it is done so before symptoms occur. Rabies usually presents as hydrophobia, prompting irrational fear of liquids and an inability to swallow saliva along with aggression and uncharacteristic behavior. In a minority of cases, it will instead cause muscle weakness and paralysis.

Leprosy – This is an ancient disease with a long-documented history of afflicting human communities. Leprosy is contagious through human-to-human contact, with speculation as to whether it can occur through contact with sweat or nasal droplets. The best way to avoid contracting this disease is to limit contact with those who are already infected

When the disease begins to present symptoms, they include characteristic pink or red patches of hard skin. Over time, these patches necrotize, and cause significant deformities in most cases, as well as nerve damage in a minority of cases. The disease is treatable, and much of the damage reversible if caught in time, though nerve damage is generally permanent.

Opportunities To Help Those In The Tropics

Many people in tropical nations experience tremendous poverty and lack access to adequate medical treatment. When this is combined with poor sanitation and climates that encourage some of the most virulent diseases, there are many opportunities for those who desire to help. Those looking to put their medical knowledge to the best use with a positive approach should prepare for the numerous diseases in the tropics. The diseases listed above are not the only ones visitors may contract, so it is essential that visitors engage in proper hygiene to kill pathogens and prevent parasitic infection, including frequently washing hands and using sanitizers. With appropriate preparation, medical professionals can safely join the fight against diseases which threaten billions around the world.