Autism

Posted on Autism

Stanford Study: Differences in Brains of Autistic Boys & Girls

CBS News Bay Area’s Amanda Starrantino talked with Kaustubh Supekar, one of the co-authors of a new Stanford Medicine study that examines differences in the brains of autistic girls and boys and explains why autism symptoms differ.

Posted on Autism

“Profound Autism” is Hidden from Social Media. Do you agree with her?

The world puts autistic people into two boxes: those seen as “different” and those seen as “disordered”. Let me be perfectly clear: I do not believe in perceptions. The world holds are useful. That said…I DO think terms like “profound autism” can be useful in securing the additional support required by folks who fit this category. People on the spectrum who are MOST vulnerable are the LEAST represented…and that needs to change!

Posted on Autism

Autistic children may have broad memory difficulties

Memory impairment in autism goes beyond poor facial recognition, a Stanford Medicine team showed. The finding suggests a wide role for memory in the neurobiology of the disorder.

A Stanford Medicine team showed that memory impairment in autism goes beyond poor facial recognition. The finding suggests a wide role for memory in the neurobiology of the disorder.
According to new research from the Stanford School of Medicine, autistic children have memory challenges that hinder not only their memory for faces but also their ability to remember other kinds of information. These impairments are reflected in distinct wiring patterns in the children’s brains.
The research clarifies a debate about memory function in autistic kids. It shows that their memory struggles surpass their ability to form social memories. According to the scientists who conducted the study, the finding should prompt broader thinking about autism in children and about treating the developmental disorder.

Memory is a key predictor of academic success, said Liu, adding that memory challenges may put kids with autism at a disadvantage in school.
The study’s findings also raise a philosophical debate about the neural origins of autism, the researchers said. Social challenges are recognized as a core feature of autism, but memory impairments might significantly contribute to the ability to engage socially.
“Social cognition can not occur without reliable memory,” said senior author Vinod Menon, PhD, the Rachael L. and Walter F. Nichols, MD, Professor and a professor of psychiatry and behavioural sciences.
“Social behaviors are complex, and they involve multiple brain processes, including associating-faces and voices to particular contexts, which require robust episodic memory,” Menon said. “Impairments in forming these associative memory traces could form one of the foundational elements in autism.”
Comprehensive memory tests
Autism, which affects about one in every 36 kids, is characterized by social impairments and restricted repetitive behaviours. The condition exists on a wide spectrum. The most severely affected individuals cannot speak or care for themselves, and about one-third of people with autism have intellectual impairments. On the other end of the spectrum, many people with high-functioning autism have normal or high IQs, complete higher education and work in a variety of fields.
Research has shown that children with autism have difficulty remembering faces. Some research has also suggested that children with autism have broader memory difficulties, but these studies were small and did not thoroughly assess participants’ memory abilities. They included children with wide ranges of age and IQ, which influence memory.
To clarify the impact of autism on memory, the new study included 25 children with high-functioning autism and normal IQ who were 8 to 12 years old, and a control group of 29 typically developing children with similar ages and IQs.


All participants completed a comprehensive evaluation of their memory skills, including their ability to remember faces, written material, and non-social photographs or photos without any people. The scientists tested participants’ ability to accurately recognize information (identifying whether they had seen an image or heard a word before) and recall it (describing or reproducing details of information they had seen or heard before). The researchers tested participants’ memory after delays of varying lengths. All participants also received functional magnetic resonance imaging scans of their brains to evaluate how regions known to be involved in memory are connected to each other.
Distinct brain networks drive memory challenges.
In line with prior research, children with autism had more difficulty remembering faces than typically developing children, the study found.
The research showed they also struggled to recall non-social information. On tests about sentences they read and non-social photos they viewed, their scores for immediate and delayed verbal recall, immediate visual recall and delayed verbal recognition were lower.
“We thought that behavioural differences might be weak because the study participants with autism had fairly high IQ, comparable to typically developing participants, but we still observed very obvious general memory impairments in this group,” Liu said.
Among typically developing children, memory skills were consistent: If a child had good memory for faces, he or she was also good at remembering non-social information.
This wasn’t the case in autism. “Among children with autism, some kids seem to have both impairments and some have more severe impairment in one area of memory or the other,” Liu said.  
The researchers had not expected this.
“It was a surprising finding that these two dimensions of memory are both dysfunctional, in ways that seem to be unrelated — and that maps onto our analysis of the brain circuitry,” Menon said.
The findings suggest that general and face-memory challenges have two underlying sources in the brain which contribute to a broader profile of memory impairments in autism.
The brain scans showed that, among the children with autism, distinct brain networks drive different types of memory difficulty.
For children with autism, the ability to retain non-social memories was predicted by connections in a network centered on the hippocampus — a small structure deep inside the brain that is known to regulate memory. But face memory in kids with autism was predicted by a separate set of connections centered on the posterior cingulate cortex, a key region of the brain’s default mode network, which has roles in social cognition and distinguishing oneself from other people.
“The findings suggest that general and face-memory challenges have two underlying sources in the brain which contribute to a broader profile of memory impairments in autism,” Menon said.
In both networks, the brains of children with autism showed over-connected circuits relative to typically developing children. Over-connectivity — likely due to too little selective pruning of neural circuits — has been found in other studies of brain networks in children with autism.
New autism therapies should account for the breadth of memory difficulties the research uncovered, as well as how these challenges affect social skills, Menon said. “This is important for functioning in the real world and for academic settings.”