How AI Could Transform ADHD Care Through Medical Chart Review

Stanford Medicine researchers uncover how AI can streamline ADHD treatment tracking.
Stanford Medicine researchers uncover how AI can streamline ADHD treatment tracking.

In a groundbreaking study, Stanford Medicine researchers have harnessed artificial intelligence (AI) to comb through thousands of doctors’ notes in electronic medical records (EMRs), revealing trends that could improve care for children with attention deficit hyperactivity disorder (ADHD). This innovative use of AI promises to relieve researchers and clinicians of tedious medical chart reviews, enabling them to focus on improving patient outcomes.

The study, published on December 19 in Pediatrics, demonstrates how large language models (LLMs) can efficiently detect gaps in ADHD management and suggest improvements. “This model enables us to identify some gaps in ADHD management,” said lead author Yair Bannett, MD, assistant professor of pediatrics at Stanford Medicine. Senior author Heidi Feldman, MD, added that the insights gained could be applied broadly across healthcare.

AI Revolutionizing ADHD Follow-Up Care

Medical records often contain critical information buried in freeform notes, making it challenging for researchers to identify patterns. For children with ADHD, proper follow-up care after starting medication is essential to monitor side effects and adjust dosages. However, manually reviewing thousands of notes is time-consuming and prone to human error.

The Stanford team trained an AI tool to analyze 15,628 notes from the medical records of 1,201 children aged 6 to 11. These children, treated across 11 pediatric practices, had been prescribed ADHD medications that can cause side effects like appetite suppression. The AI was tasked with identifying whether follow-up inquiries about side effects occurred within the first three months of medication use.

By training the model on 501 human-reviewed notes, researchers achieved 90% accuracy in classifying follow-up mentions. This AI-driven approach allowed them to analyze a task that would have otherwise taken more than seven months of full-time work.

Key Findings: Insights Beyond Human Reach

The AI model uncovered patterns that manual reviews could not. For instance, it revealed that some pediatric practices frequently conducted follow-ups via phone calls, while others did not. It also showed that doctors were less likely to ask about side effects for non-stimulant ADHD medications compared to stimulants.

“These are insights you wouldn’t detect without deploying AI across thousands of notes,” Bannett said. However, the model also highlighted its own limitations. While it identified patterns, it couldn’t explain the reasons behind them — a task that required input from pediatricians.

Challenges and Ethical Considerations

The researchers noted some limitations. The AI might have missed follow-ups recorded outside the EMRs or misclassified notes on medications unrelated to ADHD. Despite these challenges, the study highlights the importance of guiding AI tools with human expertise.

“AI is ideal for sorting through vast amounts of medical data, but ethical considerations and disparities in healthcare must remain front and center,” Bannett said. In a recent editorial, he and his colleagues emphasized the need to address biases in AI models trained on existing healthcare data.

A Vision for Personalized ADHD Care

Looking ahead, AI could help doctors make more personalized decisions for ADHD management. By analyzing large populations, AI might predict which patients are at risk of specific side effects based on age, race, genetic profile, and other factors. This capability could transform ADHD care, making it more precise and patient-centered.

“Each patient has their own experience, and with AI, we can complement that with the knowledge of large populations,” Bannett said. While the potential is immense, ensuring responsible AI deployment will be key to unlocking its full benefits for ADHD care and beyond.

This study marks a significant step toward integrating AI into routine medical care, offering a glimpse of a future where technology enhances clinicians’ ability to provide better, more tailored care.

Supporting Caregivers of Children with ADHD

A Groundbreaking Program to Enhance Psychological Wellbeing and Parenting Skills
A Groundbreaking Program to Enhance Psychological Wellbeing and Parenting Skills

Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental condition marked by inattention, impulsivity, and hyperactivity, often disrupting academic, social, and family dynamics. For parents, particularly mothers, managing ADHD can lead to significant stress, ineffective parenting practices, and strained parent-child relationships. Despite the acknowledgement of this challenge in Japan, specialized ADHD-focused parent training programs have been scarce—until now.

Researchers at the Okinawa Institute of Science and Technology (OIST) have developed Well Parent Japan (WPJ), a 13-week group-based training program designed to empower mothers of children with ADHD. The program focuses on enhancing psychological well-being, building ADHD-specific parenting skills, and fostering confidence in parenting.

Dr. Shizuka Shimabukuro, a researcher in OIST’s Human Developmental Neurobiology Unit and the program’s lead developer, has been instrumental in its creation and evaluation. Recognized with an award from Japan’s Ministry of Education, Culture, Sports, Science, and Technology (MEXT) for her contributions, Dr. Shimabukuro recently co-authored a paper published in the Journal of Child Psychology and Psychiatry. The study highlights the program’s effectiveness and cost-efficiency compared to standard treatments available in Japan.

“We implemented WPJ across three sites in Japan and found it more effective than usual treatments in these settings. Importantly, it was tested in community-based settings such as hospitals and developmental centres, rather than research labs, to ensure real-world applicability,” Dr Shimabukuro explains.


Finding Strength in Community

The program’s group-based format has proven effective in creating a supportive community for mothers who often feel isolated or hesitant to seek help.

“In Japan, mothers are typically the primary caregivers, and many feel alone in managing their children’s challenges. WPJ provides a safe, shared space where they can connect with others facing similar issues, share struggles, and learn collaboratively,” says Dr. Shimabukuro.

WPJ itself is the product of over a decade of collaboration among researchers, clinicians, parents, and children with ADHD, blending international insights with the lived experiences of Japanese families. Professor Gail Tripp, head of OIST’s Human Developmental Neurobiology Unit and a co-author of the study, highlights this collaboration as a key strength:

“We worked closely with local and university hospitals, an economist in Tokyo, and a research colleague in the UK. OIST Innovation also supported the study, helping us move toward broader implementation. It’s been a deeply collaborative effort, and it’s rewarding to see it make a difference.”


Overcoming Challenges During a Pandemic

Conducting clinical trials for WPJ was not without obstacles. The trials began shortly before the COVID-19 pandemic, requiring significant adjustments to the research design as conditions evolved.

“Coordinating trials across three sites while navigating constantly changing regulations was challenging,” recalls Dr. Shimabukuro. “I’m incredibly grateful for the commitment of the research team, who prioritized the health and safety of participants while ensuring robust data collection.”

Despite the difficulties, WPJ exceeded expectations, reducing parenting stress, enhancing parenting confidence, and alleviating family strain. Notably, the program achieved an attrition rate of just 7%, significantly lower than the typical 15% dropout rate in similar international studies under non-pandemic conditions.

“Our results show how much parents valued this program, even during such a challenging time,” says Professor Tripp.


Expanding the Program’s Reach

The success of WPJ underscores the importance of supporting caregivers as agents of change for their children. As Dr. Shimabukuro explains, “Parents need to be cared for before they can care for others.”

With the program’s demonstrated impact, Dr. Shimabukuro and her team are exploring another crucial environment for children with ADHD: schools. They are piloting an educational video series, adapted from WPJ, aimed at supporting teachers.

“Teachers spend significant time with children and face their own challenges managing ADHD-related behaviors. By equipping teachers with knowledge and practical strategies, while providing a space for them to share experiences, we can create a consistent, supportive environment for these children,” she explains.


Toward a Brighter Future

As licensed clinical psychologists, Dr. Shimabukuro and Professor Tripp are committed to blending clinical expertise and research to benefit children, families, and communities. Their ongoing efforts aim to deepen understanding of ADHD, improve access to support, and expand community resources.

“We hope to help families under strain by enhancing awareness and creating more places to receive support,” concludes Dr. Shimabukuro.

Cannabis for attention issues? How the body’s cannabinoids may influence the symptoms and treatment of ADHD

Medical cannabis relieves symptoms in children with autism

Cannabis, including marijuana and products containing cannabinoids and THC—the primary psychoactive compound in marijuana—has been hailed as a remedy for conditions ranging from anxiety and sleep issues to epilepsy and cancer pain.

Nursing researcher Dr. Jennie Ryan from Thomas Jefferson University is studying the effects of cannabis on symptoms of attention deficit hyperactivity disorder (ADHD). Current medical guidelines for treating ADHD include medications like Adderall and cognitive behavioural therapy. As with most treatments, these options can offer benefits while also presenting certain downsides. Dr. Ryan notes, “Parents are interested in cannabidiol, which does not contain THC. However, we currently lack sufficient scientific evidence to support its use.”

In a recent review paper, Dr. Ryan and her colleagues examined the scientific literature to gather evidence regarding the interactions between cannabis and ADHD. The researchers specifically focused on how cannabis use impacts ADHD symptoms. Additionally, since the human body produces its cannabinoids through the endocannabinoid system, they explored how this endogenous system might influence ADHD. They analyzed both clinical and preclinical findings, which collectively suggest that cannabis affects the endocannabinoid system in various ways, ultimately influencing attention, hyperactivity, and anxiety.

“Dr. Ryan acknowledges that there is a relationship between cannabis use and ADHD. However, she notes that this relationship is complicated by the wide variety of cannabis products available, the numerous types of endocannabinoids, their biological pathways, and the different ways ADHD can present in individuals. Separating and understanding all these factors is extremely challenging. Additionally, researchers studying cannabis face legal restrictions surrounding marijuana that hinder their efforts.”

Co-author Brooke Worster, MD, specializes in pain management and palliative care, says she suspected the published evidence would be sparse. When that was what they found, “I wasn’t super surprised,” she says. “Still, it is shocking how many holes there are. We have a lot of work ahead.”

Meltdowns in young children could be linked to ADHD, study finds

Preschool children who struggle to control their emotions and behaviour have more symptoms of attention deficit hyperactivity disorder – known as ADHD - at age seven, a study suggests.
Preschool children who struggle to control their emotions and behaviour have more symptoms of attention deficit hyperactivity disorder – known as ADHD – at age seven, a study suggests.

Preschool children who find it difficult to control their emotions and behaviour exhibit more symptoms of attention deficit hyperactivity disorder – known as ADHD – by age seven, according to a study.

Children aged between three and seven who are slower at acquiring skills to manage their intense emotions were also found to be at risk of displaying more conduct issues.

Experts say children were also more likely to show internalising behaviours at age seven, such as sadness and worries.

The study, led by the University of Edinburgh, is among the first to examine the links between early patterns of emotion regulation and school-age mental health.

The findings could help tailor targeted support for children who may benefit from enhanced preventative care before mental health issues emerge, researchers say.

Researchers at the Universities of Edinburgh, Northumbria and Oxford analysed a large dataset to test whether the progression of emotional development among children aged three to seven is related to the risk of common mental health issues.

They examined data from the UK Millennium Cohort Study, which follows the lives of around 19,000 young people born in 2000-02.

The researchers analysed questionnaires and interviews which surveyed parents on their children’s conduct, social behaviours, and emotional regulation skills.

They used statistical techniques to measure the link between emotional problems, conduct problems and ADHD symptoms at age seven.

Findings showed that a tendency to have extreme emotional responses and slower development in the ability to regulate those emotions was significantly associated with ADHD symptoms, internalising symptoms, and conduct problems in both male and female children at age seven.

This was the case even when other factors such as data on any pre-existing neurodevelopmental and mental health issues were taken into account.

Dr Aja Murray, of the University of Edinburgh’s School of Philosophy, Psychology and Language Sciences, who led the study, said: “Emotion regulation skills are acquired from early in life and are thought to strengthen gradually over childhood. Children, however, acquire these skills at different rates and slower acquisition may serve as a marker for neurodevelopmental and mental health issues. Our findings suggest that monitoring trajectories of emotion regulation over development could help identity which children are at risk of mental health issues.”

ADHD: What You Need to Know – A Q&A with Dr. Stephen Hinshaw

Attention-Deficit Hyperactivity Disorder (ADHD) is one of the most common mental health disorders in children. On Wednesday, December 4, 2024, at 7 p.m. EDT, the Brain & Behavior Research Foundation (BBRF) will host a webinar designed to help parents and educators better understand this disorder. Dr. Jeffrey Borenstein, President and CEO of BBRF, along with Dr. Stephen Hinshaw, Distinguished Professor of Psychology at the University of California, Berkeley, will discuss the symptoms of ADHD, the differences in presentation between boys and girls and will provide advice for caregivers and educators on how to help young people lead successful lives after a diagnosis.

Register HERE for this free event.

About Brain & Behavior Research Foundation 
The Brain & Behavior Research Foundation provides research grants to develop better treatments, cures, and prevention methods for mental illnesses. These include conditions such as addiction, ADHD, anxiety, autism, bipolar disorder, borderline personality disorder, depression, eating disorders, OCD, PTSD, and schizophrenia, as well as initiatives focused on suicide prevention.  Since its establishment in 1987, the Foundation has awarded over $461 million to fund more than 5,600 leading scientists worldwide. Significantly, 100% of every dollar donated is invested directly in research. The Foundation has separate grants that cover its operating expenses. Additionally, BBRF produces the Emmy®-nominated public television series “Healthy Minds” with Dr. Jeffrey Borenstein, which seeks to reduce the stigma surrounding mental illness and illustrates that there is hope for recovery with assistance.