A new paper-based biosensor system uses bacterial spores germinating in response to glucose in potassium-rich bodily fluids like sweat. Credit Sean Choi
Millions of people with diabetes endure daily finger-stick tests to monitor their glucose levels. Imagine if they could track their glucose levels just by sweating. Researchers at Binghamton University, State University of New York, suggest using sweat sensors instead of blood samples for glucose monitoring.
Their innovative research proposes a paper-based biosensor system utilizing Bacillus subtilis bacterial spores that react to glucose in sweat. The reaction produces power, which indicates glucose levels.
This groundbreaking study, led by Professor Seokheun “Sean” Choi, Assistant Professor Anwar Elhadad, and PhD student Yang “Lexi” Gao, offers a promising alternative to traditional enzymatic blood tests. Unlike enzymes, bacterial spores are stable, enduring harsh conditions and activating only under the right circumstances.
Due to enzyme instability, glucose monitoring methods aren’t easily stored or shipped. The new system’s spore-based approach could revolutionize diabetes management by providing a more durable and convenient solution.
Gao, who has a background in marine chemistry, has been an integral part of this research. Despite the challenges of the COVID-19 pandemic, she has published numerous papers and contributed significantly to the project’s success. Her previous experience in “papertronics” and biobatteries aligns perfectly with this innovative study.
As the team continues to refine the device, they aim to improve its sensitivity and better understand the impact of varying potassium concentrations in sweat on glucose detection. This research represents a significant step towards a pain-free, more efficient method of monitoring glucose levels in diabetics.