Can multiple sclerosis cause pain? Yes, it can! This video highlights 11 common pain syndromes associated with MS, including trigeminal neuralgia, the “MS hug,” neuropathic pain, muscle spasms, and several others.
Age-related brain atrophy refers to the gradual loss of neurons and shrinkage of brain tissue, which is a natural part of the ageing process. This condition can contribute to cognitive decline and various neurological issues. While ageing itself cannot be prevented, recent research from an 18-month dietary intervention provides hope that lifestyle and dietary changes may help slow down brain ageing.
Brain age, determined through MRI measurements of the hippocampus and lateral ventricles, reflects the biological aging of the brain, which may differ from a person’s chronological age. Chronological age is simply the number of years a person has lived, while brain age indicates the actual health of the brain. Generally, as we age, the hippocampus tends to shrink, and the lateral ventricles tend to expand, which serve as indicators of brain ageing. Some individuals may have a brain age that is younger or older than their chronological age. A younger brain age suggests better cognitive health, whereas an older brain age may indicate accelerated ageing and an increased risk of cognitive decline.
The study found that a decline in HbA1c and key markers of long-term blood sugar levels is associated with significant positive changes in specific brain regions commonly affected by age-related atrophy. It suggests that improved blood sugar control could be one of the most important factors in slowing down age-related brain changes.
Previous research has shown the benefits of the Green Mediterranean (Green-Med) diet, particularly its positive effects on blood sugar control. This diet is rich in polyphenols from plant-based sources such as Mankai—a high-protein aquatic plant—and green tea, while being low in red and processed meats. The current study reinforces these findings, suggesting that the Green-Med diet not only supports metabolic health but may also have protective effects on brain structure and function.
Researchers have long believed that the keto diet could help reduce an overactive immune system and benefit individuals with conditions such as multiple sclerosis.
Now, they have reason to believe it could be true.
Scientists at UC San Francisco have discovered that the diet makes the gut and its microbes produce two factors that attenuated symptoms of MS in mice.
If the study translates to humans, it points toward a new way of treating MS and other autoimmune disorders with supplements.
The keto diet severely restricts carbohydrate-rich foods like bread, pasta, fruit and sugar but allows unlimited fat consumption.
Without carbohydrates to use as fuel, the body breaks down fat instead, producing compounds called ketone bodies. Ketone bodies provide energy for cells to burn and can change the immune system.
Working with a mouse model of MS, the researchers found that mice who produced more of a particular ketone body, called β-hydroxybutyrate (βHB), had less severe disease.
The additional βHB also prompted the gut bacterium Lactobacillus murinus to produce an indole lactic acid (ILA) metabolite. This blocked the activation of T helper 17 immune cells involved in MS and other autoimmune disorders.
“What was exciting was discovering that we could protect these mice from inflammatory diseases simply by putting them on a diet supplemented with these compounds,” said Peter Turnbaugh, PhD, of the Benioff Center for Microbiome Medicine.
Earlier, Turnbaugh had shown that when secreted by the gut, βHB counteracts immune activation. This prompted a postdoctoral scholar working in his lab, Margaret Alexander, PhD, to see if the compound could ease the symptoms of MS in mice.
In the new study, which appears Nov. 4 in Cell Reports, the team examined how the ketone body-rich diet affected mice unable to produce βHB in their intestines and found that their inflammation was more severe.
However, when the researchers supplemented their diets with βHB, the mice got better.
To find out how βHB affects the gut microbiome, the team isolated bacteria from the guts of three mice fed either the keto diet, a high-fat diet, or the βHB supplemented high-fat diet.
Then, they screened the metabolic products of each group’s distinct microbes in an immune assay and determined that the diet’s positive effects were coming from a member of the Lactobacillus genus: L. murinus.
Two other techniques, genome sequencing and mass spectrometry, confirmed that the L. murinus they found produced indole lactic acid, which is known to affect the immune system.
Finally, the researchers treated the MS mice with either ILA or L. murinus, improving their symptoms.
Turnbaugh cautioned that the supplement approach still needs to be tested in people with autoimmune disorders.
“The big question now is how much of this will translate into actual patients,” he said. “But I think these results provide hope for the development of a more tolerable alternative to helping those people than asking them to stick to a challenging restrictive diet.”
Chronic lower back pain is very common—up to 20% of adults worldwide have long-lasting or recurrent lower back pain. The pain can make walking, sleeping, working, or doing daily activities difficult in severe cases.
Clinical guidelines recommend the use of non-pharmacologic treatments first, such as physical therapy or in-person yoga classes. This study examined whether virtual yoga classes would also be effective for the treatment of chronic low back pain. The findings show that participants who practised virtual yoga classes reported reduced back pain intensity and improved back-related function.
“Attending yoga classes in person can be challenging,” said Robert Saper, M.D., MPH, chair of the Department of Wellness and Preventive Medicine at Cleveland Clinic, and senior author of the study. “This research shows that a virtual yoga class program can be a safe and effective therapeutic option for the treatment of chronic low back pain.”
Researchers performed a 24-week randomized clinical trial that involved 140 eligible participants with chronic low back pain. The average age of the participants was 48 and more than 80% were female. The study participants were members of Cleveland Clinic’s Employee Health Plan from Northeast Ohio and Florida. The study was conducted from May 2022 through May 2023.
The research team conducted assessments to determine baseline measures, such as pain intensity score and back-related function using the Roland Morris Disability Questionnaire. Participants were then randomly assigned to either the “yoga now” group or the “yoga later” control group.
Seventy-one participants were enrolled in the yoga now group, which included virtual live-streamed yoga group classes for 12 weeks followed by a 12-week assessment period. Sixty-nine participants were enrolled in the yoga later control group and continued with their usual medical care. After the research ended, the yoga later group was offered non-study yoga classes.
Cleveland Clinic yoga instructors delivered a 12-week program designed to maximize effectiveness and safety, adapted for virtual delivery, and intended for participants with chronic low back pain.
Following the baseline assessment, participants were reassessed at six weeks, 12 weeks, and 24 weeks for low back pain intensity, back-related function, pain-medication use, and sleep quality.
At the end of the 12-week virtual yoga program, yoga now participants reported six times greater reductions in pain intensity scores and 2.7 times more significant improvements in back-related function compared with participants who had not taken the yoga classes.
Additionally, 34% fewer patients in the yoga now group reported using pain medication, and they reported 10 times greater improvement in sleep quality compared to the yoga later group. At 24 weeks, the improvements in pain and back-related function were sustained.
“Yoga offers a comprehensive approach to managing low back pain, a condition for which traditional treatments often fall short,” said Hallie Tankha, Ph.D., research faculty in the Department of Wellness and Preventive Medicine at Cleveland Clinic, and first author of the study. “Now we must work to increase access to this safe and effective treatment.”
Dr Saper plans to continue this vital research with a more extensive and more diverse sample of patients from multiple healthcare systems.
