Autistic youth with should be screened for abnormal cholesterol levels, physicians recommend

Cholesterol
Cholesterol


Physicians at Kennedy Krieger Institute  recommend that children with autism receive screening for abnormally high or low cholesterol levels at least once during their childhood, as autism is a risk factor for cardiovascular disease in both children and adults.

The recommendation resulted from a recent study that found reduced levels of high density lipoprotein cholesterol (HDL-C), known as the good cholesterol, in individuals from families with two or more children with autism . In addition, they found reduced or elevated levels of other lipids, apolipoprotein A1 (ApoA1) and apolipoprotein B (ApoB).  Individuals with low HDL-C levels or ApoA1 levels had lower adaptive functioning than other individuals with autism.

“This latest research is part of our ongoing work to understand some of the co-occurring conditions with autism,” said Elaine Tierney, MD, a child and adolescent psychiatrist with Kennedy Krieger Institute. “Our work indicates that lipids are abnormal in many individuals with autism . Our findings, in addition to studies that show an increase in heart disease in individuals with autism, lead us to recommend that children with autism be screened for abnormal total and HDL cholesterol levels. We hope our work underscores the importance of cholesterol screening and raises awareness for families in the autism community.”

Prior to the completion of this research, Dr. Tierney and her colleagues identified that Smith-Lemli-Opitz Syndrome (SLOS), a genetic condition of impaired cholesterol biosynthesis, is associated with autism. A 2007 study completed by her and other researchers led to a recommendation that all children with autism be screened for SLOS if they exhibit some of its characteristics, such as slow growth, microcephaly, mental retardation and other birth defects, although the severity of this rare disease can vary.

As an extension of this latest study, Dr. Tierney and researchers with the Department of Genetics, Genomics and Informatics at the University of Tennessee Health Science Center are performing analyses of whole genome sequencing data with study participants to determine if there are lipid-related genetic alterations in patients with autism and abnormal lipid levels. A next step for the research team is to study populations of individuals who have only one person in their family with autism to see if the abnormal cholesterol and other lipid levels are different in those families than they are in families with at least two individuals with autism .

Not all “good” cholesterol is healthy

Cholesterol
Cholesterol


HDL cholesterol (high-density lipoprotein cholesterol) or good cholesterol is associated with a decreased risk of cardiovascular disease as it transports cholesterol deposited in the arteries to the liver to be eliminated. This contrasts with the so-called bad cholesterol, LDL (low-density lipoprotein cholesterol), which causes cholesterol to accumulate in the arteries and increases cardiovascular risk. Although drugs that lower bad cholesterol reduce cardiovascular risk, those that raise good cholesterol have not proven effective in reducing the risk of heart disease. This paradox has called into question the relationship between good cholesterol and cardiovascular risk, and researchers are now studying the characteristics of these HDL or good cholesterol particles.

A study led by the Hospital del Mar Medical Research Institute (IMIM), published in the journal Metabolism, Clinical and Experimental, has now demonstrated that not all good cholesterol is healthy. Researchers from the CIBER on Cardiovascular Diseases (CIBERCV), the CIBER on Obesity and Nutrition (CIBEROBN), and the CIBER on Epidemiology and Public Health (CIBERESP), as well as others from Hospital Clínic-IDIBAPS, IDIBELL, the Hospital de la Santa Creu i Sant Pau Research Institute, and the Hospital Clínico Universitario in Zaragoza also took part in this study.

In the work, the researchers analysed genetic characteristics that determine the size of good cholesterol particles, and then studied their relationship with the risk of myocardial infarction. The conclusion is that genetic characteristics linked to the generation of large good cholesterol particles are directly associated with a higher risk of heart attack, while features linked to small good cholesterol particles are related to a lower risk of heart attack. “There is a positive causal relationship between the size of HDL cholesterol particles and the risk of heart attack, so although we have to increase the levels of good cholesterol in the blood, they must always be small particles”, explains the study’s principal investigator, Dr. Robert Elosua, a researcher at the Hospital del Mar-IMIM, CIBERCV, and the University of Vic-Central University of Catalonia (UVic-UCC).

The good cholesterol particles are more effective in transferring cholesterol to the liver so that it can be eliminated. “If we need to do something in relation to HDL, it is to increase the number of small particles, which are those that adequately perform the function of eliminating cholesterol, those that really move it to the liver for removal, and do not allow it to accumulate in the arteries and cause cardiovascular disease”, says Dr. Álvaro Hernáez, a IDIBAPS and CIBEROBN researcher.

Currently, there are no drugs that increase good cholesterol levels and reduce the risk of cardiovascular disease. “This study highlights new and potential therapeutic targets in the field of cardiovascular diseases, including several genes related to the qualitative aspects of HDL particles, which may contribute to cardiovascular prevention”, concludes Dr. Albert Prats, a researcher in the Epidemiology and Cardiovascular Genetics Research Group at the Hospital del Mar-IMIM and first author of the study.

How to Make Sense of Your Cholesterol Levels





Cholesterol isn’t a plague that you need to avoid. In fact, cholesterol is required in several important body functions. Yet conventional doctors often neglect to tell you this and unnecessarily prescribe statins or cholesterol-lowering drugs, putting you at risk of well-documented side effects.

It’s time for you to learn the truth about cholesterol, and the better indicators of heart disease than just your total cholesterol level. Check out this infographic and help educate others by sharing this with your friends and family.




cholesterol levels infographic

Learn the better indicator of heart disease risk than just your total cholesterol – plus the dangers of statins and the need to supplement with CoQ10 if you’re taking these cholesterol-lowering drugs – through our infographic “How to Make Sense of Your Cholesterol Levels.” Use the embed code to share it on your website or visit our infographic page for the high-res version.

<img src="https://media.mercola.com/assets/images/infographic/cholesterol-levels-infographic.png" alt="cholesterol levels infographic" border="0" style="max-width:100%; min-width:300px; margin: 0 auto 20px auto; display:block;"><p style="max-width:800px; min-width:300px; margin:0 auto; text-align:center;">Learn the better indicator of heart disease risk than just your total cholesterol - plus the dangers of statins and the need to supplement with CoQ10 if you're taking these cholesterol-lowering drugs - through our infographic "<a href="http://www.mercola.com/infographics/cholesterol-levels.htm">How to Make Sense of Your Cholesterol Levels</a>." Visit our infographic page for the high-res version.</p>




Cholesterol – what you need to know and why




Cholesterol

Cholesterol

Cholesterol is a fatty substance known as a lipid and is vital for the normal functioning of the body. It’s mainly made by the liver, but can also be found in some foods.

Having an excessively high level of lipids in your blood (hyperlipidemia) can have an effect on your health.

High cholesterol itself doesn’t usually cause any symptoms, but it increases your risk of serious health conditions.

About cholesterol

Cholesterol is carried in your blood by proteins. When the two combine, they’re called lipoproteins.


The two main types of lipoprotein are:

high-density lipoprotein (HDL) – carries cholesterol away from the cells and back to the liver, where it’s either broken down or passed out of the body as a waste product; for this reason, HDL is referred to as “good cholesterol”, and higher levels are better

low-density lipoprotein (LDL) – carries cholesterol to the cells that need it, but if there’s too much cholesterol for the cells to use, it can build up in the artery walls, leading to disease of the arteries; for this reason, LDL is known as “bad cholesterol”

The amount of cholesterol in the blood – both HDL and LDL – can be measured with a blood test.

The recommended cholesterol levels in the blood vary between those with a higher or lower risk of developing arterial disease.

Why should I lower my cholesterol?

Evidence strongly indicates that high cholesterol can increase the risk of:

narrowing of the arteries (atherosclerosis)

heart attack

stroke

transient ischaemic attack (TIA) – often known as a “mini stroke”

peripheral arterial disease (PAD)

This is because cholesterol can build up in the artery wall, restricting the blood flow to your heart, brain and the rest of your body. It also increases the risk of a blood clot developing somewhere in your body.

Your risk of developing coronary heart disease also rises as your blood’s cholesterol level increases. This can cause pain in your chest or arm during stress or physical activity (angina).

What causes high cholesterol?

Many factors can increase your chances of having heart problems or a stroke if you have high cholesterol.

These include:

an unhealthy diet – in particular, eating high levels of saturated fat

smoking – a chemical found in cigarettes called acrolein stops HDL transporting cholesterol from fatty deposits to the liver, leading to narrowing of the arteries (atherosclerosis)

having diabetes or high blood pressure (hypertension)

having a family history of stroke or heart disease

There’s also an inherited condition called familial hypercholesterolaemia, which can cause high cholesterol even in someone who eats healthily.




Read more about the causes of high cholesterol.

When should my cholesterol levels be tested?

Your GP may recommend that you have your blood cholesterol levels tested if you:

have been diagnosed with coronary heart disease, stroke or mini stroke (TIA), or peripheral arterial disease (PAD)

have a family history of early cardiovascular disease

have a close family member who has a cholesterol-related condition

are overweight

have high blood pressure, diabetes, or a health condition that can increase cholesterol levels

Read more about how cholesterol is tested.

What should my cholesterol levels be?

Blood cholesterol is measured in units called millimoles per litre of blood, often shortened to mmol/L.

As a general guide, total cholesterol levels should be:

5mmol/L or less for healthy adults

4mmol/L or less for those at high risk

As a general guide, LDL levels should be:

3mmol/L or less for healthy adults

2mmol/L or less for those at high risk

An ideal level of HDL is above 1mmol/L. A lower level of HDL can increase your risk of heart disease.

Your ratio of total cholesterol to HDL may also be calculated. This is your total cholesterol level divided by your HDL level. Generally, this ratio should be below four, as a higher ratio increases your risk of heart disease.

However, cholesterol is only one risk factor and the level at which specific treatment is required will depend on whether other risk factors, such as smoking and high blood pressure, are also present.

How can I lower my cholesterol level?

The first step in reducing your cholesterol is to maintain a healthy, balanced diet. It’s important to keep your diet low in fatty food.

You can swap food containing saturated fat for fruit, vegetables and wholegrain cereals. This will also help prevent high cholesterol returning.

Other lifestyle changes, such as taking regular exercise and giving up smoking (if you smoke), can also make a big difference in helping to lower your cholesterol.

If these measures don’t reduce your cholesterol and you continue to have a high risk of developing heart disease, your GP may prescribe a cholesterol-lowering medication, such as statins.

Your GP will take into account the risk of any side effects from statins, and the benefit of lowering your cholesterol must outweigh any risks.

Read more about how high cholesterol is treated.

Kimchee – What are the health benefits of kimchee!


Kimchee - what are the benefits to our health

Kimchee – what are the benefits to our health

Never heard of kimchee?  Then let me be the one to introduce you this really amazing (and healthy) food.

But before I start I should explain that my love of kimchee is about 25 years old now.  It started in a sadly long defunct restaurant in South Wimbledon, London whose name escapes me for the moment. (It was great and real shame it closed.)




The evening we went (a Saturday I think) my eating life changed.  For the first time I tried Kimchee – the spicy fermented cabbage which is the hallmark of Korean food.    Talking to the gentleman who ran the place I was told that there are around 100,000 different types of fermented and picked vegetable dishes on the peninsula.  It was then a decided (by my wife and I) that our next holiday had to be to Korea. When we went we find it was (and still was on subsequent visits) a paradise for those who love hot and tasty food, wonderful people, great scenery and some of the finest sights in Asia.  (Ad for Korea over but do go… you won’t regret it).

Back now to the discussion of kimchee and why it is good for you.

As you may have picked up fermented foods (such as sauerkraut) are the fashion of the moment.  Kimchee comes into this category of tasty things.

The first point is that kimchi (an alternative spelling) is low in calories and high in fibre which makes it a great part of a weight loss program!

Secondly it is very high in vitamins.  In particular vitamin A, vitamin B1, vitamin B2 and vitamin C.  I’m told that the vitamin C content is upped by the fermentation process.

Kimchee is also a great source of antioxidants.  You can read up about the benefits of anti-oxidants at our previous blog.

But most importantly it is probiotic.  According to the NHS “Probiotics are live bacteria and yeasts promoted as having various health benefits. They’re usually added to yoghurts or taken as food supplements, and are often described as ‘good’ or ‘friendly’ bacteria.”  Again we have a whole blogful of data here on probiotics.

So what is Kimchi useful for health-wise?

  1. Diabetes comes to mind. Koreans, it seems, have a lower incidence than say the
    Kimchi - why it is great for you

    Kimchi – why it is great for you

    US and this has been attributed to the kimchi in the diet.  And it does help reduce blood sugar levels.

  2. Yes I was a bit surprised by this as well!  But again the great bacteria produced by eating kimchee do their job!
  3. Lowers cholesterol. Now kimchi has a high level of garlic which may well help reduce Cholesterol.
  4. Boost the immune system.
  5. General digestive health including bowel problems. Here both the fibre and the bacteria come into play.
  6. Aids weight loss and helps fight obesity!
  7. Anti-aging properties. Collagen produced by the bacteria helps keep you skin in tip top condition!

So where can I get kimchee?  Well these days a lot of supermarket chain sell it otherwise specialist Asian stores are your beast!

Otherwise you might even want to consider making your own.  Here is the recipe I use.

PS  I should mention that kimchi smells quite strong.  So both my wife and I have had complaints when we have taken it into work.

PPS It is not just vegetables which are fermented.  I once tried fermented fish guts.  You should too.