Investigators have developed a freely available measure of autism symptoms that can help to screen for autism and monitor changes over time in symptoms. Research on the development and validation of the Autism Symptom Dimension Questionnaire (ASDQ) is published in Developmental Medicine & Child Neurology.
After development of an initial 33-item version, a revised 39-item version of the ASDQ (available at https://prolific.co/) was applied to 1,467 children and adolescents, including 104 with autism spectrum disorder. The questionnaire was found to be reliable and valid for evaluating autism symptoms across age, sex, race, and ethnicity.
“Having a freely available and modern measure of autism symptoms can greatly improve clinical practice and advance research into autism spectrum disorder,” said corresponding author Thomas W. Frazier, PhD, of John Carroll University.
Chemical “micromotors,” as illustrated here, can effectively deliver insulin in rats without an injection. CREDIT Adapted from ACS Nano, 2022, DOI: 10.1021/acsnano.2c07953
For millions of people living with diabetes, insulin is a life-saving drug. Unlike many other medicines, though, insulin cannot be easily delivered by swallowing a pill — it needs to be injected under the skin with a syringe or pump. Researchers have been making steps toward an insulin pill. A team reports in ACS Nano that they’ve delivered insulin to the colons of rats using an orally administered tablet powered by chemical “micromotors.”
Patients with diabetes have trouble regulating their blood glucose levels because they produce little or no insulin. Synthetic insulin has existed for over a hundred years, but it is often administered with an injection or an implanted pump. People affected by diabetes often take insulin multiple times per day so frequent injections can be painful, and as a result, some patients do not take the recommended dose at the correct times.
An oral form of the drug would be ideal, but the stomach’s harsh environment breaks down and neutralizes the hormone before it can be absorbed by the intestines and get into the bloodstream. Previous attempts at oral administration protected the hormone from stomach acids with micro- or nanocarriers. Still, they relied on insulin to diffuse passively into the cells that line the colon, which isn’t very efficient. A better approach could be actively moving the medicine around the body instead, such as with a recently reported Robo-capsule that delivers its cargo by drilling itself into the thick mucosal layer of the small intestine. Yingfeng Tu, Fei Peng, Kun Liu and colleagues wanted to achieve a similar effect with their insulin-loaded mini-tablets, which featured tiny, chemical “micromotors” that could deliver insulin to the colon safely and effectively.
To make these tablets, the researchers covered magnesium microparticles with a layer of an insulin-containing solution and a layer of liposomes. They then mixed these particles with baking soda, pressed them into mini-tablets about 3 mm long then covered them with an esterified starch solution. The starch protected the tablets from stomach acid, allowing them to reach the colon intact. As they broke down, the magnesium microparticles reacted with water to generate a stream of hydrogen gas bubbles, which acted as micromotors that propelled insulin toward the colon’s lining to be absorbed. The team also tested their mini-tablets in rats and found that they could significantly reduce the animals’ blood glucose levels for over five hours. In fact, they could maintain a glucose level almost as low as injection-delivered insulin. Though more work is needed, the researchers say that this is a concrete step toward creating more oral formulations of traditionally injection-only medications.
I asked Twitter 23 questions about multiple sclerosis, and 52% of the answers were correct. Watch the video and pause on each question to see if you can beat them. Even if you don’t want to play along, you’ll definitely learn something by watching the video.
As more U.S. states legalize cannabis (also known as marijuana) for medical and recreational use, increasing numbers of people are experimenting with it for pain relief. According to a new study published in JAMA Network Open, almost a third of patients with chronic pain reported using cannabis to manage it.
More than half of the 1,724 adults surveyed reported that using cannabis led them to decrease the use of pain medications, including prescription opioids and over-the-counter analgesics. Cannabis also affected the use of other non-drug related pain relief methods to various degrees. Some people indicated that cannabis led them to turn less often to techniques that many clinical guidelines recommend as first-line therapies such as physical therapy and cognitive behavioural therapy. In contrast, others with chronic pain increased their use of such treatments.
“The fact that patients report substituting cannabis for pain medications so much underscores the need for research on the benefits and risk of using cannabis for chronic pain,” said Mark Bicket, M.D., Ph.D., Assistant Professor in the Department of Anesthesiology and Co-Director of the Michigan Opioid Prescribing Engagement Network.
On this video I explore some of the #autistic traits in adults that you may have never realised were signs of #autism. Plus, I share my personal lived experiences as an #actuallyautistic person.
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